Growing evidence suggests a possible link between hyperpolarization-activated cyclic
nucleotide-gated nonselective cation (HCN) channels and depression. In a recent study …

Hyperpolarization-activated cyclic nucleotide–gated (HCN) channels function in the brain to
limit neuronal excitability. Limiting the activity of these channels has been proposed as a …

Active coping is an adaptive stress response that improves outcomes in medical and
neuropsychiatric diseases. To date, most research into coping style has focused on …

Dendritic ion channels play a critical role in shaping synaptic input and are fundamentally
important for synaptic integration and plasticity. In the hippocampal region CA1, somato …

Alzheimer's disease (AD) affects both grey and white matter (WM), but considerably more is
known about the former. Interestingly, WM disruption has been consistently observed and …

The hyperpolarization-activated cyclic nucleotide-gated channels are cation channels that
are activated by hyperpolarizing potentials. These channels are concentrated in cortical and …

Hyperpolarization-activated cyclic nucleotide-gated cation channel 1 (HCN1) is
predominantly expressed in neurons from the neocortex and hippocampus, two important …

Hippocampus, Model Excitatory Cells, Fig. 1 The morphology of principal cells of the CA1,
CA3, and dentate gyrus.(a) A CA1 pyramidal cell.(b) A CA3 pyramidal cell. Note that the cell …

Tetratricopeptide repeat (TPR) domains are ubiquitous structural motifs that mediate protein–
protein interactions. For example, the TPR domains in the peroxisomal import receptor PEX5 …

Uncovering the physiological role of individual proteins that are part of the intricate process
of cellular signaling is often a complex and challenging task. A straightforward strategy of …