Network pharmacology in research of Chinese medicine formula: methodology, application and prospective

T Luo, Y Lu, S Yan, X Xiao, X Rong, J Guo - Chinese journal of integrative …, 2020 - Springer
Chinese medicine (CM) is usually prescribed as CM formula to treat disease. The lack of
effective research approach makes it difficult to elucidate the molecular mechanisms of CM …

Natural products as a source for antifibrosis therapy

DQ Chen, YL Feng, G Cao, YY Zhao - Trends in pharmacological sciences, 2018 - cell.com
Although fibrosis is a final pathological feature of many chronic diseases, few interventions
are available that specifically target the pathogenesis of fibrosis. Natural products are …

[HTML][HTML] Gut microbiota-involved mechanisms in enhancing systemic exposure of ginsenosides by coexisting polysaccharides in ginseng decoction

SS Zhou, J Xu, H Zhu, J Wu, JD Xu, R Yan, XY Li… - Scientific Reports, 2016 - nature.com
Oral decoctions of traditional Chinese medicines (TCMs) serve for therapeutic and
prophylactic management of diseases for centuries. Small molecules and polysaccharides …

Novel applications of mass spectrometry‐based metabolomics in herbal medicines and its active ingredients: current evidence

XJ Wang, JL Ren, AH Zhang, H Sun… - Mass Spectrometry …, 2019 - Wiley Online Library
Current evidence shows that herbal medicines could be beneficial for the treatment of
various diseases. However, the complexities present in chemical compositions of herbal …

Hepatoprotective mechanism of Silybum marianum on nonalcoholic fatty liver disease based on network pharmacology and experimental verification

G Jiang, C Sun, X Wang, J Mei, C Li, H Zhan… - …, 2022 - Taylor & Francis
The study aimed to identify the key active components in Silybum marianum (S. marianum)
and determine how they protect against nonalcoholic fatty liver disease (NAFLD). TCMSP …

[HTML][HTML] Roles and mechanisms of puerarin on cardiovascular disease: a review

Z Jiang, X Cui, P Qu, C Shang, M Xiang… - Biomedicine & …, 2022 - Elsevier
Cardiovascular diseases (CVDs) are now the leading cause of mortality and morbidity
worldwide, resulting in a large global economic burden. Recently, complementary and …

[HTML][HTML] An integrated chinmedomics strategy for discovery of effective constituents from traditional herbal medicine

X Wang, A Zhang, X Zhou, Q Liu, Y Nan, Y Guan… - Scientific reports, 2016 - nature.com
Traditional natural product discovery affords no information about compound structure or
pharmacological activities until late in the discovery process and leads to low probabilities of …

[HTML][HTML] Screening and evaluation of anti-SARS-CoV-2 components from Ephedra sinica by ACE2/CMC-HPLC-IT-TOF-MS approach

Y Lv, S Wang, P Liang, Y Wang, X Zhang, Q Jia… - Analytical and …, 2021 - Springer
Traditional Chinese medicines played an important role in the treatment of COVID-19 in
2020. Ephedra sinica, one of the major constituent herbs of multi-component herbal formula …

A systems approach to traditional oriental medicine

HU Kim, JY Ryu, JO Lee, SY Lee - Nature biotechnology, 2015 - nature.com
A systems approach to traditional oriental medicine | Nature Biotechnology Skip to main
content Thank you for visiting nature.com. You are using a browser version with limited support …

Dioscin inhibits the growth of human osteosarcoma by inducing G2/M‐phase arrest, apoptosis, and GSDME‐dependent cell death in vitro and in vivo

Q Ding, W Zhang, C Cheng, F Mo… - Journal of cellular …, 2020 - Wiley Online Library
Pyroptosis is a form of programmed cell death (PCD) that plays a vital role in immunity and
diseases. Although it was recently reported that chemotherapy drugs can induce pyroptosis …