Biomarkers for early cancer detection: A landscape view of recent advancements, spotlighting pancreatic and liver cancers

R Tenchov, AK Sapra, J Sasso, K Ralhan… - ACS Pharmacology & …, 2024 - ACS Publications
Cancer is one of the leading causes of death worldwide. Early cancer detection is critical
because it can significantly improve treatment outcomes, thus saving lives, reducing …

Noncoding RNAs and programmed cell death in hepatocellular carcinoma: Significant role of epigenetic modifications in prognosis, chemoresistance, and tumor …

R Arefnezhad, S Ashna… - Cell Biology …, 2024 - Wiley Online Library
Hepatocellular carcinoma (HCC) is the most common type of liver cancer with a high death
rate in the world. The molecular mechanisms related to the pathogenesis of HCC have not …

[HTML][HTML] Nivolumab in sorafenib-naive and sorafenib-experienced patients with advanced hepatocellular carcinoma: 5-year follow-up from CheckMate 040

AB El-Khoueiry, J Trojan, T Meyer, T Yau, I Melero… - Annals of …, 2024 - Elsevier
Background Patients with advanced hepatocellular carcinoma (aHCC) have a poor
prognosis and high mortality. Nivolumab monotherapy demonstrated clinical benefit with an …

Discovering novel prognostic biomarkers of hepatocellular carcinoma using eXplainable Artificial Intelligence

E Gutierrez-Chakraborty, D Chakraborty, D Das… - Expert Systems with …, 2024 - Elsevier
Hepatocellular carcinoma (HCC) remains a global health challenge with high mortality rates,
largely due to late diagnosis and suboptimal efficacy of current therapies. With the …

Laser-printed paper ELISA and hydroxyapatite immobilization for colorimetric congenital anomalies screening in saliva

H Moulahoum, F Ghorbanizamani, S Timur - Analytica Chimica Acta, 2024 - Elsevier
Background Alpha-fetoprotein (AFP) is a fetal protein that can indicate congenital anomalies
such as Down syndrome and spinal canal blockage when detected at abnormal levels in …

Prognostic Role of Basal Serum Alpha-Fetoprotein in Patients with Hepatocellular Carcinoma Suitable for Curative Treatment

S Mazza, C Frigerio, D Alfieri, A Mauro, F Torello Viera… - Medicina, 2024 - mdpi.com
Background and Objectives: Serum alpha-fetoprotein (AFP) is a recognized affordable
oncological marker in patients with hepatocellular carcinoma (HCC). However, AFP's …

Targeting AFP-RARβ complex formation: a potential strategy for treating AFP-positive hepatocellular carcinoma

B Banjan, R Vishwakarma, K Ramakrishnan, RR Dev… - Molecular Diversity, 2024 - Springer
Alpha-fetoprotein (AFP) is a glycoprotein primarily expressed during embryogenesis, with
declining levels postnatally. Elevated AFP levels correlate with pathological conditions such …

Development of Machine Learning-Based Personalized Predictive Models for Early Detection of Hepatocellular Carcinoma in HBV-Related Cirrhosis Patients with …

Y Xu, JY Xu, H Hu, B Zhang, F Zhou, X Yang, O Xiao - 2023 - researchsquare.com
Background: The continuous increase in the incidence of HCC in China is an urgent issue,
and early diagnosis and treatment are crucial. This study aims to create personalized …