Concentrations at which global gene expression profiles in cells or animals exposed to a
test substance start to differ significantly from those of controls have been proposed as an …

Multiple in vivo test guidelines focusing on the estrogen, androgen, thyroid, and
steroidogenesis pathways have been developed and validated for mammals, amphibians …

Assessment of ecological risks of chemicals in the field usually involves complex mixtures of
known and unknown compounds. We describe the use of pathway‐based chemical and …

There is ample evidence that a range of anthropogenic chemicals occur in the aquatic
environment, some of which have the potential to cause harm. Contaminants of Emerging …

This chapter aims to introduce the reader to the basic principles of environmental risk
assessment of chemicals and highlights the usefulness of tiered approaches within weight of …

There are insufficient toxicity data to assess the ecological risks of many pharmaceuticals
and personal care products (PPCPs). While data limitations are not uncommon for …

A set of adverse outcome pathways (AOPs) linking inhibition of thyroperoxidase and
deiodinase to impaired swim bladder inflation in fish has recently been developed. These …

Environmental challenges persist across the world, including the Australasian region of
Oceania, where biodiversity hotspots and unique ecosystems such as the Great Barrier Reef …

A systematic review was conducted on the sensitivity of fish testing guidelines to detect the
anti-androgenic activity of substances. Sequence Alignment to Predict Across Species …

Cell-based assays utilizing reporter gene technology have been widely exploited for
biosensing, as they provide useful information about the bioavailability and cell toxicity of …