Evidenced-based approaches to support the development of endocrine-mediated adverse outcome pathways: challenges and opportunities
K Audouze, E Zgheib, K Abass, AH Baig… - Frontiers in …, 2021 - frontiersin.org
Adverse outcome pathways (AOP) have captured the attention of regulators and researchers
alike as a systematic approach for organizing toxicological knowledge. AOPs can help …
alike as a systematic approach for organizing toxicological knowledge. AOPs can help …
Characterizing physical protein targets of chemical contaminants with chemical proteomics: Is it time to fill a crucial environmental toxicology knowledge gap?
DR Hall, H Peng - Comparative Biochemistry and Physiology Part D …, 2020 - Elsevier
Current environmental toxicological studies are challenged by the immense number (>
80,000) of chemical contaminants. While several strategies including adverse outcome …
80,000) of chemical contaminants. While several strategies including adverse outcome …
Commentary: Assessing the endocrine disrupting effects of chemicals on invertebrates in the European Union
M Crane, S Dungey, A Lillicrap, H Thompson… - Environmental Sciences …, 2022 - Springer
Evidence from both laboratory and field studies has shown that currently used synthetic and
naturally occurring chemical substances may potentially disrupt invertebrate endocrine …
naturally occurring chemical substances may potentially disrupt invertebrate endocrine …
Health of wild fish exposed to contaminants of emerging concern in freshwater ecosystems utilized by a Minnesota Tribal community
Fish serve as indicators of exposure to contaminants of emerging concern (CECs)—
chemicals such as pharmaceuticals, hormones, and personal care products—which are …
chemicals such as pharmaceuticals, hormones, and personal care products—which are …
Simultaneous determination of a suite of endogenous steroids by LC-APPI-MS: Application to the identification of endocrine disruptors in aquatic toxicology
BR Blackwell, GT Ankley - Journal of Chromatography B, 2021 - Elsevier
Exposure to endocrine-disrupting compounds (EDCs) can alter steroid hormone production
in vertebrates, sometimes leading to adverse reproductive or developmental effects. Liquid …
in vertebrates, sometimes leading to adverse reproductive or developmental effects. Liquid …
Differential Sensitivity to In Vitro Inhibition of Cytochrome P450 Aromatase (CYP19) Activity Among 18 Freshwater Fishes
JA Doering, DL Villeneuve, KA Fay… - Toxicological …, 2019 - academic.oup.com
There is significant concern regarding potential impairment of fish reproduction associated
with endocrine disrupting chemicals. Aromatase (CYP19) is a steroidogenic enzyme …
with endocrine disrupting chemicals. Aromatase (CYP19) is a steroidogenic enzyme …
Combination of computational new approach methodologies for enhancing evidence of biological pathway conservation across species
The ability to predict which chemicals are of concern for environmental safety is dependent,
in part, on the ability to extrapolate chemical effects across many species. This work …
in part, on the ability to extrapolate chemical effects across many species. This work …
In vitro assessment of thyroid peroxidase inhibition by chemical exposure: comparison of cell models and detection methods
R Liu, J Novák, K Hilscherová - Archives of Toxicology, 2024 - Springer
Disruption of the thyroid hormone (TH) system is connected with diverse adverse health
outcomes in wildlife and humans. It is crucial to develop and validate suitable in vitro assays …
outcomes in wildlife and humans. It is crucial to develop and validate suitable in vitro assays …
Conversion of estrone to 17β‐estradiol: A potential confounding factor in assessing risks of environmental estrogens to fish
MA Tapper, RC Kolanczyk, CA LaLone… - Environmental …, 2020 - Wiley Online Library
Feminization of male fish and the role of endocrine‐active chemicals in this phenomenon
has been an area of intense study for many years. Estrone (E1), a natural steroid, is found in …
has been an area of intense study for many years. Estrone (E1), a natural steroid, is found in …
Projection of Interspecific Competition (PIC) Matrices: A Conceptual Framework for Inclusion in Population Risk Assessments
DH Miller, CA LaLone, DL Villeneuve… - Environmental …, 2024 - Wiley Online Library
Accounting for intraspecific and interspecific competition when assessing the effects of
chemical and nonchemical stressors is an important uncertainty in ecological risk …
chemical and nonchemical stressors is an important uncertainty in ecological risk …