[HTML][HTML] Comparative analysis between zebrafish and an automated live-cell assay to classify developmental neurotoxicant chemicals
LS Mary, L Truong, AA Bieberich, RO Fatig III… - Toxicology and Applied …, 2023 - Elsevier
Modern toxicology's throughput has dramatically increased due to alternative models,
laboratory automation, and machine learning. This has enabled comparative studies across …
laboratory automation, and machine learning. This has enabled comparative studies across …
Evaluation of a multiplexed, multispecies nuclear receptor assay for chemical hazard assessment
Sensitivity to potential endocrine disrupting chemicals in the environment varies across
species and is influenced by sequence conservation of their nuclear receptor targets. Here …
species and is influenced by sequence conservation of their nuclear receptor targets. Here …
Neglected impacts of plant protection products on invertebrate aquatic biodiversity: a focus on eco-evolutionary processes
MA Coutellec, A Chaumot, E Sucré - Environmental Science and Pollution …, 2024 - Springer
The application of plant protection products (PPPs) may have delayed and long-term non-
intentional impacts on aquatic invertebrates inhabiting agricultural landscapes. Such effects …
intentional impacts on aquatic invertebrates inhabiting agricultural landscapes. Such effects …
Exploring the potential of ToxCast™ data for mechanism-based prioritization of chemicals in regulatory context: Case study with priority existing chemicals (PECs) …
Recent studies have highlighted the potential of the ToxCast™ database for mechanism-
based prioritization of chemicals. To explore the applicability of ToxCast data in the context …
based prioritization of chemicals. To explore the applicability of ToxCast data in the context …
Assessing utility of thyroid in vitro screening assays through comparisons to observed impacts in vivo
SA Eytcheson, JH Olker, KP Friedman… - Regulatory Toxicology …, 2023 - Elsevier
To better understand endocrine disruption, the US Environmental Protection Agency's
(USEPA) Endocrine Disruptor Screening Program (EDSP) utilizes a two-tiered approach to …
(USEPA) Endocrine Disruptor Screening Program (EDSP) utilizes a two-tiered approach to …
Adverse Outcome Pathway on Aromatase inhibition leading to male-biased sex ratio via impacts on gonad differentiation
KJS Rodriguez, DL Villeneuve, KM Jensen, GT Ankley… - 2023 - oecd-ilibrary.org
This adverse outcome pathway links inhibition of aromatase activity in teleost fish during
gonadogenesis to increased differentiation to testis resulting in a male-biased sex ratio in …
gonadogenesis to increased differentiation to testis resulting in a male-biased sex ratio in …
Cashmeran as a potential endocrine disrupting chemical: What does the weight-of-the-evidence indicate?
S Tayal, MA Schults, P Sterchele, E Hulzebos… - Food and Chemical …, 2023 - Elsevier
Cashmeran is a fragrance ingredient. Risk assessments are available but have not focused
on its endocrine disruptor potential. The objective was to evaluate Cashmeran as a potential …
on its endocrine disruptor potential. The objective was to evaluate Cashmeran as a potential …
Cross-species molecular docking method to support predictions of species susceptibility to chemical effects
The advancement of protein structural prediction tools, exemplified by AlphaFold and
Iterative Threading ASSEmbly Refinement, has enabled the prediction of protein structures …
Iterative Threading ASSEmbly Refinement, has enabled the prediction of protein structures …
Leveraging ToxCast data and protein sequence conservation to complement aquatic life criteria derivation
The USEPA's 1985 guidelines for the derivation of aquatic life criteria (ALC) are robust but
data‐intensive. For many chemicals, the extensive in vivo data sets required for ALC …
data‐intensive. For many chemicals, the extensive in vivo data sets required for ALC …
Current testing programs for pesticides adequately capture endocrine activity and adversity for protection of vertebrate wildlife
JP Staveley, EL Freeman, ME McArdle… - Integrated …, 2023 - Wiley Online Library
The toxicity and ecotoxicity of pesticide active ingredients are evaluated by a number of
standardized test methods using vertebrate animals. These standard test methods are …
standardized test methods using vertebrate animals. These standard test methods are …