Despite recent advances, cytomegalovirus (CMV) infections remain one of the most common
complications affecting solid organ transplant recipients, conveying higher risks of …

Whole-genome sequencing (WGS) of pathogens is becoming increasingly important not
only for basic research but also for clinical science and practice. In virology, WGS is …

Despite advances in preventive strategies, cytomegalovirus (CMV) infection remains a major
complication in solid organ and hematopoietic cell transplant recipients. CMV infection may …

Cytomegalovirus (CMV) infection is a significant complication in hematopoietic cell
transplantation (HCT) recipients. Four antiviral drugs are used for preventing or treating …

Letermovir (LMV) is an experimental cytomegalovirus terminase inhibitor undergoing phase
3 clinical trials. Viral mutations have been described at UL56 codons 231 to 369 that confer …

Next-generation sequencing (NGS) technologies are increasingly being used for diagnosis
and monitoring of infectious diseases. Herein, we review the application of NGS in clinical …

Hosts with compromised or naive immune systems, such as individuals living with HIV/AIDS,
transplant recipients, and fetuses, are at the highest risk for complications from …

Cytomegalovirus (CMV) drug resistance mutation maps are updated with recent information
for polymerase inhibitors, the terminase inhibitor letermovir and the UL97 kinase inhibitor …

Background In separate phase 2 trials, 120 patients received maribavir for cytomegalovirus
(CMV) infection failing conventional therapy (trial 202) and 119 received maribavir for …

Mutations in CMV genes can be selected during antiviral drug exposure, and manifests
phenotypically as nonresponsive drug-resistant disease. Knowledge of specific mutations …