IgG4 characteristics and functions in cancer immunity
IgG4 is the least abundant subclass of IgG in normal human serum, but elevated IgG4 levels
are triggered in response to a chronic antigenic stimulus and inflammation. Since the …
are triggered in response to a chronic antigenic stimulus and inflammation. Since the …
[HTML][HTML] Alternative pathways of non-homologous end joining (NHEJ) in genomic instability and cancer
R Dueva, G Iliakis - Translational cancer research, 2013 - tcr.amegroups.org
An incompletely defined alternative non-homologous end joining pathway (A-NHEJ)
frequently functioning as backup has recently been shown to process DNA double strand …
frequently functioning as backup has recently been shown to process DNA double strand …
Comprehensive endometrial immunoglobulin subclass analysis in infertile women suffering from repeated implantation failure with or without chronic endometritis
K Kitaya, Y Tada, T Hayashi, S Taguchi… - American journal of …, 2014 - Wiley Online Library
Problem Chronic endometritis (CE) is a local inflammatory condition with unusual
plasmacyte infiltration in the endometrial stromal area. CE is frequently found in infertile …
plasmacyte infiltration in the endometrial stromal area. CE is frequently found in infertile …
Intrinsic B cell TLR-BCR linked coengagement induces class-switched, hypermutated, neutralizing antibody responses in absence of T cells
Maturation of antibody responses entails somatic hypermutation (SHM), class-switch DNA
recombination (CSR), plasma cell differentiation, and generation of memory B cells, and it is …
recombination (CSR), plasma cell differentiation, and generation of memory B cells, and it is …
The importance of B cell receptor isotypes and stereotypes in chronic lymphocytic leukemia
B cell receptor (BCR) signaling is a central pathway promoting the survival and proliferation
of normal and malignant B cells. Chronic lymphocytic leukemia (CLL) arises from mature B …
of normal and malignant B cells. Chronic lymphocytic leukemia (CLL) arises from mature B …
More than one antibody of individual B cells revealed by single-cell immune profiling
Antibodies have a common structure consisting of two identical heavy (H) and two identical
light (L) chains. It is widely accepted that a single mature B cell produces a single antibody …
light (L) chains. It is widely accepted that a single mature B cell produces a single antibody …
Activation induced cytidine deaminase: An old friend with new faces
E Çakan, G Gunaydin - Frontiers in Immunology, 2022 - frontiersin.org
Activation induced cytidine deaminase (AID) protein is a member of APOBEC family. AID
converts cytidine to uracil, which is a key step for somatic hypermutation (SHM) and class …
converts cytidine to uracil, which is a key step for somatic hypermutation (SHM) and class …
Bioengineering translational models of lymphoid tissues
YS Michaels, CF Buchanan, N Gjorevski… - Nature Reviews …, 2023 - nature.com
Bioengineered models of human tissues have the potential to revolutionize human health by
providing a translational platform to investigate disease mechanisms and develop new …
providing a translational platform to investigate disease mechanisms and develop new …
Histone deacetylase inhibitors upregulate B cell microRNAs that silence AID and Blimp-1 expression for epigenetic modulation of antibody and autoantibody …
Class-switch DNA recombination (CSR) and somatic hypermutation (SHM), which require
activation-induced cytidine deaminase (AID), and plasma cell differentiation, which requires …
activation-induced cytidine deaminase (AID), and plasma cell differentiation, which requires …
Regulation of AID, the B-cell genome mutator
C Keim, D Kazadi, G Rothschild… - Genes & …, 2013 - genesdev.cshlp.org
The mechanisms by which B cells somatically engineer their genomes to generate the vast
diversity of antibodies required to challenge the nearly infinite number of antigens that …
diversity of antibodies required to challenge the nearly infinite number of antigens that …