Cuproptosis: mechanisms and links with cancers

J Xie, Y Yang, Y Gao, J He - Molecular cancer, 2023 - Springer
Cuproptosis was a copper-dependent and unique kind of cell death that was separate from
existing other forms of cell death. The last decade has witnessed a considerable increase in …

[HTML][HTML] Copper homeostasis and copper-induced cell death: novel targeting for intervention in the pathogenesis of vascular aging

Z Chen, Y Li, X Liu - Biomedicine & Pharmacotherapy, 2023 - Elsevier
Copper-induced cell death, also known as cuproptosis, is distinct from other types of cell
death such as apoptosis, necrosis, and ferroptosis. It can trigger the accumulation of lethal …

A novel cuproptosis-related lncRNA signature predicts the prognosis and immune landscape in bladder cancer

Y Bai, Q Zhang, F Liu, J Quan - Frontiers in Immunology, 2022 - frontiersin.org
Background Bladder cancer (BLCA) is one of the deadliest diseases, with over 550,000 new
cases and 170,000 deaths globally every year. Cuproptosis is a copper-triggered …

Definition of a novel Cuproptosis‐relevant lncRNA signature for uncovering distinct survival, genomic alterations, and treatment implications in lung adenocarcinoma

Z Wang, J Yao, T Dong, X Niu - Journal of Immunology …, 2022 - Wiley Online Library
Objective. Cuproptosis is a newly discovered copper‐independent cell death modality, and
limited evidence suggests the critical implications in human cancers. Nonetheless, the …

Bioinformatics prediction and experimental validation identify a novel cuproptosis-related gene signature in human synovial inflammation during osteoarthritis …

W Wang, Z Chen, Y Hua - Biomolecules, 2023 - mdpi.com
Osteoarthritis (OA) is the one of most common joint diseases worldwide. Cuproptosis, which
had been discovered lately, is a novel form of cell death induced by copper. Our purpose is …

Identification and development of a novel risk model based on cuproptosis-associated RNA methylation regulators for predicting prognosis and characterizing immune …

D Li, Z Shi, X Liu, S Jin, P Chen, Y Zhang, G Chen… - Hepatology …, 2023 - Springer
Background Cuproptosis, a novel cell death caused by excess copper, is quite obscure in
hepatocellular carcinoma (HCC) and needs more investigation. Methods RNA-seq and …

Contribution of cuproptosis and Cu metabolism‐associated genes to chronic obstructive pulmonary disease

W Qi, L Liu, Q Zeng, Z Zhou, D Chen… - Journal of cellular …, 2023 - Wiley Online Library
Airway epithelial cell injury plays a crucial role in the pathogenesis of chronic obstructive
pulmonary disease (COPD). However, a novel form of Cu‐induced programmed cell death …

Role of cuproptosis in understanding diseases

S Cao, Q Wang, Z Sun, Y Zhang, Q Liu, Q Huang… - Human Cell, 2023 - Springer
Cell death is involved in a wide range of physiological and pathological processes.
Recently, the term “cuproptosis” was coined to describe a novel type of cell death. This type …

Identification and validation of BCL6 and VEGFA as biomarkers and ageing patterns correlating with immune infiltrates in OA progression

Z Chen, W Wang, Y Hua - Scientific Reports, 2023 - nature.com
Osteoarthritis (OA), the most common type of arthritis, is a complex biological response
caused by cartilage wear and synovial inflammation that links biomechanics and …

Crosstalk between metabolism and cell death in tumorigenesis

S Yang, C Hu, X Chen, Y Tang, J Li, H Yang, Y Yang… - Molecular Cancer, 2024 - Springer
It is generally recognized that tumor cells proliferate more rapidly than normal cells. Due to
such an abnormally rapid proliferation rate, cancer cells constantly encounter the limits of …