This paper reviews recent developments in the neurocircuitry and neurobiology of addiction
from a perspective of allostasis. A model is proposed for brain changes that occur during the …

Most prior research on the neurobiology of addiction has focused on the role of subcortical
systems, such as the amygdala, the ventral striatum and mesolimbic dopamine system, in …

Behavioral studies have suggested that exaggerated reactivity to food cues, especially those
associated with high-calorie foods, may be a factor underlying obesity. This increased …

A decision-making instrument known as the 'gambling task'was used, which has been
shown to be sensitive to the decision-making impairment of patients with bilateral lesions of …

Drug addiction can be conceptualized as a disturbance of behavior motivated by drug-
conditioned incentives. This abnormality has been explained by Incentive-Sensitization and …

The amphetamine derivative (±)-3, 4-methylenedioxymethamphetamine (MDMA, ecstasy) is
a popular recreational drug among young people, particularly those involved in the dance …

This review provides a neuroadaptive perspective regarding the role of the hormonal and
brain stress systems in drug addiction with a focus on the changes that occur during the …

Delay discounting (DD) is a measure of the degree to which an individual is driven by
immediate gratification vs. the prospect of larger, but delayed, rewards. Because of …

The mesolimbic dopaminergic (ML-DA) system has been recognized for its central role in
motivated behaviors, various types of reward, and, more recently, in cognitive processes …

Substance use disorders (SUDs) manifest as chronic relapsing disorders, characterized by
compulsive drug taking despite serious adverse consequences, the loss of control over …