Astroglia are a broad class of neural parenchymal cells primarily dedicated to homoeostasis
and defence of the central nervous system (CNS). Astroglia contribute to the …

Over the last 15 years, the field of neuroscience has evolved toward recognizing the critical
role of astroglia in shaping neuronal synaptic activity and along with the pre-and …

Background The formation and retrieval of fear memories depends on orchestrated synaptic
activity of neuronal ensembles within the hippocampus, and it is becoming increasingly …

Clinical and preclinical studies indicate that adaptations in corticostriatal neurotransmission
significantly contribute to heroin relapse vulnerability. In animal models, heroin self …

Chronic use of drugs of abuse affects neuroimmune signaling; however, there are still many
open questions regarding the interactions between neuroimmune mechanisms and …

Drug addiction remains a key biomedical challenge facing current neuroscience research. In
addition to neural mechanisms, the focus of the vast majority of studies to date, astrocytes …

Astrocytes are fundamental building blocks of the central nervous system. Their dysfunction
has been implicated in many psychiatric disorders, including alcohol use disorder, yet our …

Substance use disorder (SUD) is characterized, in part by behavior biased toward drug use
and away from natural sources of reward (eg, social interaction, food, sex). The …

Highlights•NAcore astrocytes undergo morphological remodeling after addictive drug use
resulting in their reduced synaptic proximity.•Repeated self-administration of …

Antipsychotic-induced dopamine supersensitivity, or behavioral supersensitivity, is a
problematic consequence of long-term antipsychotic treatment characterized by the …