Cerebral palsy is a clinical descriptor covering a diverse group of permanent, non-
degenerative disorders of motor function. Around one-third of cases have now been shown …

In 1959, 63 years after the death of John Langdon Down, Jérôme Lejeune discovered
trisomy 21 as the genetic reason for Down syndrome. Screening for Down syndrome has …

During the last decades several lines of evidence reported the association of an adverse
intrauterine environment, leading to intrauterine restriction, with future disease, such as …

Objective This study aimed to determine the incremental yield of prenatal exome
sequencing over chromosomal microarray or G-banding karyotype in fetuses with:(1) …

Individuals born extremely preterm are at significant risk for impaired neurodevelopment.
After discharge from the neonatal intensive care, associations between the child's well-being …

Fetal growth restriction (FGR) is one of the most formidable challenges in present-day
antenatal care. Pathological fetal growth is a well-known factor of not only in utero demise in …

Objective To determine how various centile cut points on the INTERGROWTH-21st
(INTERGROWTH), World Health Organization (WHO), and Hadlock fetal growth charts …

The aim of this study was to determine the diagnostic yield of exome sequencing (ES) above
that of chromosomal microarray analysis (CMA) or karyotyping in fetuses with isolated fetal …

Objective To investigate the association between preconception maternal retinal arteriolar
calibre and fetal growth. Design, setting and population A hospital‐based, prospective …

Objectives: The aims of the study were to assess the false-positive and uninformative test
rate with first trimester cell-free DNA (cfDNA) screening for common trisomies and …