Insulin and glucagon exert opposing effects on glucose metabolism and, consequently,
pancreatic islet β-cells and α-cells are considered functional antagonists. The intra-islet …

The evolution of glucagon has seen the transition from an impurity in the preparation of
insulin to the development of glucagon receptor agonists for use in type 1 diabetes. In type 2 …

Glucagon, a hormone secreted from the α-cells of the endocrine pancreas, is critical for
blood glucose homeostasis. It is the major counterpart to insulin and is released during …

In 1960, immunoassays of insulin first demonstrated significant quantities of circulating
hormone in non-insulin-dependent (type II) diabetes and for 30 yr have fostered debate as to …

The hyperglycemic activity of pancreatic extracts was encountered some 80 yr ago during
efforts to optimize methods for the purification of insulin. The hyperglycemic substance was …

A brief review of the normal physiology of insulin secretion is given. The dual role of glucose
to directly stimulate insulin release and to potentiate insulin secretion to other islet regulators …

The mechanisms by which hypoglycemia stimulates glucagon release are still poorly
understood. In particular, the relative importance of direct metabolic coupling versus …

Aims/hypothesis The mechanisms by which glucose regulates glucagon release are poorly
understood. The present study aimed to clarify the direct effects of glucose on the glucagon …

Presents an analysis of the conditioning of drug effects that permits the prediction of the
nature and direction of conditioned responses and accounts for drug-conditioning results …

The circadian rhythmicity of endogenous metabolic and hormonal processes is controlled by
a complex system of central and peripheral pacemakers, influenced by exogenous factors …