Myocardial infarction (MI) is the most common cause of a heart failure, which occurs due to
myocardial ischemia leading to left ventricular (LV) remodeling. LV remodeling particularly …

Recent advancement in understanding the complex characters and interdependent
molecular pathways of biological diseases led to a new therapeutic approach of “Biological …

Purpose The absence of clinically applicable imaging techniques for continuous monitoring
of transplanted cells poses a significant obstacle to the clinical translation of stem cell-based …

Cardiac stem cell therapy continues to hold promise for the treatment of ischemic heart
disease despite the fact that early promising pre-clinical findings have yet to be translated …

Background Hepatocyte growth factor (HGF) is one of the major angiogenic factors being
studied for the treatment of ischemic heart diseases. Our previous study demonstrated …

Heart failure is a devastating disease with high morbidity and mortality. In 2013,
approximately 5.1 million people suffered from chronic heart failure in the United States. 1 …

The experience accumulated in cardiac cell therapy suggests that regeneration of
extensively necrotic myocardial areas is unlikely to be achieved by the sole paracrine effects …

The understanding of the engrafted cell behaviors such as the survival, growth and
distribution is the prerequisite to optimize cell therapy, and a multimodal imaging at both …

Regenerative medicine uses stem cells to repair damaged tissue. Imaging plays a key role
in this process because imaging can reveal the location of cells and how they are interacting …

Abstract Background Manganese-enhanced MRI (MEMRI) detects viable cardiomyocytes
based on the intracellular manganese uptake via L-type calcium-channels. This study aimed …