Perivascular inflammation is a prominent pathologic feature in most animal models of
pulmonary hypertension (PH) as well as in pulmonary arterial hypertension (PAH) patients …

This review summarizes an expanding body of knowledge indicating that failure to resolve
inflammation and altered immune processes underlie the development of pulmonary arterial …

Knowledge of the pathobiology of pulmonary hypertension (PH) continues to accelerate.
However, fundamental gaps remain in our understanding of the underlying pathological …

Pulmonary vascular remodeling is the key structural alteration in pulmonary hypertension
and involves changes in the intima, media and adventitia, often with the interplay of …

Pulmonary arterial hypertension (PAH) is a progressive disease characterized by lung
endothelial cell dysfunction and vascular remodeling. Normally, the endothelium forms an …

The vascular adventitia acts as a biological processing center for the retrieval, integration,
storage, and release of key regulators of vessel wall function. It is the most complex …

Pulmonary arterial hypertension (PAH) is characterized by remodeling of the extracellular
matrix (ECM) of the pulmonary arteries with increased collagen deposition, cross-linkage of …

Rationale: Pulmonary arterial hypertension (PAH) often results in death from right ventricular
failure (RVF). NLRP3 (nucleotide-binding domain, leucine-rich-containing family, pyrin …

Rationale: Accumulating evidence implicates inflammation in pulmonary arterial
hypertension (PAH) and therapies targeting immunity are under investigation, although it …

Pulmonary hypertension (PH) is characterized by increased proliferation and apoptosis
resistance of pulmonary artery smooth muscle cells (PASMCs). Forkhead box O (FoxO) …