Human CYP1A2 is one of the major CYPs in human liver and metabolizes a number of
clinical drugs (eg, clozapine, tacrine, tizanidine, and theophylline; n> 110), a number of …

Human cytochrome P450 1A2 (CYP1A2) is one of the major CYPs in the liver (&sim13%)
and metabolizes about 20% of clinically used drugs. CYP1A2 is a 515-residue protein with a …

The purpose of this study was to investigate the in vitro inhibition potential of the three
purified herbal constituents tetrahydropalmatine (Tet), neferine (Nef) and berberine (Ber) …

The cytochrome P450 enzyme CYP1A2 is crucial for the metabolism of many drugs, for
example, tizanidine. As the effects of several non‐steroidal anti‐inflammatory drugs (NSAID) …

Background A simple method to predict drug–drug interactions mediated by cytochrome
P450 enzymes (CYPs) on the basis of in vivo data has been previously applied for several …

Tolfenamic acid (TA) is a nonsteroidal antiinflammatory drug and belongs to the group of
fenamates. It is used as a potent pain reliever in the treatment of acute migraine attacks, and …

(‒)-Sophoranone (SPN) is a bioactive component of Sophora tonkinensis with various
pharmacological activities. This study aims to evaluate its in vitro and in vivo inhibitory …

Objective The purpose of this work is to evaluate the in vitro inhibitory effect of magnolol
(MN) and honokiol (HN) on rat/human cytochrome P450 (CYP) enzymes (1A2/1A2, 2D/2D6 …

The aim of this study was to determine whether mexiletine, a CYP1A2 inhibitor, altered the
pharmacokinetics and pharmacodynamics of tizanidine. The pharmacokinetics of tizanidine …

Propranolol, the substrate of cytochrome P450 (CYP) 1A2 and CYP2D6, has been reported
to be in high concentrations in end‐stage renal disease (ESRD) patients. This has been …