The immune composition of the tumor microenvironment regulates processes including
angiogenesis, metastasis, and the response to drugs or immunotherapy. To facilitate the …

Background Adoptive T-cell therapy relying on conventional T cells transduced with T-cell
receptors (TCRs) or chimeric antigen receptors (CARs) has caused substantial tumor …

Melanoma is the least common form of skin cancer and is associated with the highest
mortality. Where melanoma is mostly unresponsive to conventional therapies (eg …

Introduction of a tumor antigen-specific T cell receptor (TCR) into patient-derived
lymphocytes has already exhibited promising results for the treatment of melanoma and …

Because of the poor prognosis and of oral mucosal melanoma, and patients' short survival,
large, randomised, clinical studies are difficult. We have investigated its demographic …

Aberrant anti-cancer drug efflux mediated by membrane protein ABC transporters (ABCB5
and ABCG2) is thought to characterize melanoma heterogeneous chemoresistant …

Despite melanoma immunogenicity and remarkable therapeutic effects of negative immune
checkpoint inhibitors, a significant fraction of patients does not respond to current treatments …

Accumulating evidence indicated that aberrantly expressed microRNAs play critical roles in
the initiation and progression of human cancers. However, the underlying functions of miR …

Objectives The purpose of this multicenter retrospective study was to investigate the
demographic characteristics and treatment outcomes of patients with mucosal malignant …

Melanoma is one of the most common malignant tumors that originate from nerve sheath
melanocytes and are produced in the skin and other organs. This paper mainly studied the …