Polypharmacy in older adults: a narrative review of definitions, epidemiology and consequences

F Pazan, M Wehling - European geriatric medicine, 2021 - Springer
Background The number of older adults has been constantly growing around the globe.
Consequently, multimorbidity and related polypharmacy have become an increasing …

An overview of prevalence, determinants and health outcomes of polypharmacy

M Khezrian, CJ McNeil, AD Murray… - … advances in drug …, 2020 - journals.sagepub.com
A high rate of polypharmacy is, in part, a consequence of the increasing proportion of
multimorbidity in the ageing population worldwide. Our understanding of the potential harm …

An update on the clinical consequences of polypharmacy in older adults: a narrative review

JW Wastesson, L Morin, ECK Tan… - Expert opinion on drug …, 2018 - Taylor & Francis
Introduction: Polypharmacy, the use of multiple medications by one individual, is
increasingly common among older adults. Caring for the growing number of older people …

[HTML][HTML] Adverse outcomes of polypharmacy in older people: systematic review of reviews

LE Davies, G Spiers, A Kingston, A Todd… - Journal of the American …, 2020 - Elsevier
Objective Polypharmacy is widespread among older people, but the adverse outcomes
associated with it are unclear. We aim to synthesize current evidence on the adverse health …

3D printing pharmaceuticals: drug development to frontline care

SJ Trenfield, A Awad, A Goyanes, S Gaisford… - Trends in …, 2018 - cell.com
3D printing (3DP) is forecast to be a highly revolutionary technology within the
pharmaceutical sector. In particular, the main benefits of 3DP lie in the production of small …

Polypharmacy, hospitalization, and mortality risk: a nationwide cohort study

TI Chang, H Park, DW Kim, EK Jeon, CM Rhee… - Scientific reports, 2020 - nature.com
Polypharmacy is a growing and major public health issue, particularly in the geriatric
population. This study aimed to examine the association between polypharmacy and the risk …

The relationship between frailty and polypharmacy in older people: a systematic review

M Gutiérrez‐Valencia, M Izquierdo… - British journal of …, 2018 - Wiley Online Library
Aims Frailty is a complex geriatric syndrome resulting in decreased physiological reserves.
Frailty and polypharmacy are common in older adults and the focus of extensive studies …

Alzheimer's disease microbiome is associated with dysregulation of the anti-inflammatory P-glycoprotein pathway

JP Haran, SK Bhattarai, SE Foley, P Dutta, DV Ward… - MBio, 2019 - Am Soc Microbiol
The microbiota-gut-brain axis is a bidirectional communication system that is poorly
understood. Alzheimer's disease (AD), the most common cause of dementia, has long been …

The silent epidemic of chronic pain in older adults

AF Domenichiello, CE Ramsden - Progress in Neuro-Psychopharmacology …, 2019 - Elsevier
Chronic pain is highly prevalent among older adults where it is associated with significant
suffering, disability, social isolation, and greater costs and burden to health care systems …

Reorganisation of primary care for older adults during COVID-19: a cross-sectional database study in the UK

M Joy, D McGagh, N Jones, H Liyanage… - British Journal of …, 2020 - bjgp.org
Background The coronavirus disease 2019 (COVID-19) pandemic has resulted in a rapid
change in workload across healthcare systems. Factors related to this adaptation in UK …