[HTML][HTML] Epigenetic codes for heterochromatin formation and silencing: rounding up the usual suspects

EJ Richards, SCR Elgin - Cell, 2002 - cell.com
Recent results from diverse organisms point to a self-reinforcing network of interactions
among the three best-characterized covalent modifications that mark heterochromatin …

Environmentally induced phenotypes and DNA methylation: how to deal with unpredictable conditions until the next generation and after

B Angers, E Castonguay, R Massicotte - Molecular Ecology, 2010 - Wiley Online Library
Organisms often respond to environmental changes by producing alternative phenotypes.
Epigenetic processes such as DNA methylation may contribute to environmentally induced …

Genetic association studies: design, analysis and interpretation

CM Lewis - Briefings in bioinformatics, 2002 - academic.oup.com
This paper provides a review of the design and analysis of genetic association studies. In
case control studies, the different contingency tables and their relationships to the …

The DNMT3B DNA methyltransferase gene is mutated in the ICF immunodeficiency syndrome

RS Hansen, C Wijmenga, P Luo… - Proceedings of the …, 1999 - National Acad Sciences
DNA methylation is an important regulator of genetic information in species ranging from
bacteria to humans. DNA methylation appears to be critical for mammalian development …

Engineered nucleic acids and methods of use thereof

JP Schrum, S Bancel, NB Afeyan - US Patent 8,822,663, 2014 - Google Patents
NOESYZHRGYRDHS-UHFFFAOYSA-N insulin Chemical compound N1C (= O) C (NC (= O)
C (CCC (N)= O) NC (= O) C (CCC (O)= O) NC (= O) C (C (C) C) NC (= O) C (NC (= O) CN) C …

Modified polynucleotides for the production of biologics and proteins associated with human disease

S Bancel, T Chakraborty, A De Fougerolles… - US Patent …, 2015 - Google Patents
First worldwide family litigation filed litigation Critical https://patents. darts-ip. com/? family=
49235350&utm_source= google_patent&utm_medium= platform_link&utm_campaign …

Modified polynucleotides for the production of secreted proteins

T Chakraborty, A De Fougerolles - US Patent 9,192,651, 2015 - Google Patents
First worldwide family litigation filed litigation Critical https://patents. darts-ip. com/? family=
49235350&utm_source= google_patent&utm_medium= platform_link&utm_campaign …

Pharmaceutical composition containing a stabilised mRNA optimised for translation in its coding regions

F Von Der Mülbe, I Hoerr, S Pascolo - US Patent 10,188,748, 2019 - Google Patents
The present invention relates to a pharmaceutical composi tion comprising a modified
mRNA that is stabilized by sequence modifications and optimized for translation. The …

Periodic DNA methylation in maize nucleosomes and demethylation by environmental stress

N Steward, M Ito, Y Yamaguchi, N Koizumi… - Journal of Biological …, 2002 - ASBMB
When maize seedlings were exposed to cold stress, a genome-wide demethylation occurred
in root tissues. Screening of genomic DNA identified one particular fragment that was …

Structure, function and evolution of CpG island promoters

F Antequera - Cellular and Molecular Life Sciences CMLS, 2003 - Springer
Mammalian promoters belong to two different categories in terms of base composition and
DNA methylation. In humans and mice, approximately 60% of all promoters colocalize with …