Nrf2 modulation in breast cancer

S Ghareghomi, M Habibi-Rezaei, M Arese, L Saso… - Biomedicines, 2022 - mdpi.com
Reactive oxygen species (ROS) are identified to control the expression and activity of
various essential signaling intermediates involved in cellular proliferation, apoptosis, and …

[HTML][HTML] Brusatol: a potential sensitizing agent for cancer therapy from Brucea javanica

T He, F Zhou, A Su, Y Zhang, Z Xing, L Mi, Z Li… - Biomedicine & …, 2023 - Elsevier
Cancer is currently the most important problem endangering human health. As antitumor
drugs have always been the most common methods for treating cancers, searching for new …

Alkaloids as natural NRF2 inhibitors: Chemoprevention and cytotoxic action in Cancer

D Gjorgieva Ackova, V Maksimova, K Smilkov… - Pharmaceuticals, 2023 - mdpi.com
Being a controller of cytoprotective actions, inflammation, and mitochondrial function through
participating in the regulation of multiple genes in response to stress-inducing endogenous …

Design, Synthesis, and Anti-Breast Cancer Potential of Imidazole–Pyridine Hybrid Molecules In Vitro and Ehrlich Ascites Carcinoma Growth Inhibitory Activity …

B Aruchamy, MG Kuruburu, VR Bovilla… - ACS …, 2023 - ACS Publications
Breast cancer remains a challenging medical issue and is a high priority for biomedical
research despite significant advancements in cancer research and therapy. The current …

Natural compounds, optimal combination of brusatol and polydatin promote anti-tumor effect in breast cancer by targeting nrf2 signaling pathway

J Li, J Zhang, Y Zhu, LO Afolabi, L Chen… - International Journal of …, 2023 - mdpi.com
Triple-negative breast cancer (TNBC) has been clearly recognized as a heterogeneous
tumor with the worst prognosis among the subtypes of breast cancer (BC). The advent and …

Mir-140-5p attenuates hypoxia-induced breast cancer progression by targeting nrf2/ho-1 axis in a keap1-independent mechanism

M Mahajan, S Sitasawad - Cells, 2021 - mdpi.com
Hypoxia and oxidative stress significantly contribute to breast cancer (BC) progression.
Although hypoxia-inducible factor 1α (Hif-1α) is considered a key effector of the cellular …

The transcription factor NRF2 has epigenetic regulatory functions modulating HDACs, DNMTs, and miRNA biogenesis

I Silva-Llanes, CH Shin, J Jiménez-Villegas… - Antioxidants, 2023 - mdpi.com
The epigenetic regulation of gene expression is a complex and tightly regulated process that
defines cellular identity and is associated with health and disease processes. Oxidative …

[HTML][HTML] Variations in the anticancer activity of free and bound phenolics of finger millet (Eleusine coracana (L) Gaertn; variety KMR-301) seeds

MG Kuruburu, VR Bovilla, R Naaz, Z Leihang… - Phytomedicine Plus, 2022 - Elsevier
ABSTRACT Background Finger millet (FM, Eleusine coracana (L) Gaertn; also known as
“ragi” in Kannada language) is one of the widely used millets especially in south India and …

Cyperotundone combined with adriamycin induces apoptosis in MCF-7 and MCF-7/ADR cancer cells by ROS generation and NRF2/ARE signaling pathway

W Shao, X Wang, Z Liu, X Song, F Wang, X Liu… - Scientific Reports, 2023 - nature.com
Breast cancer has become the most prevalent cancer, globally. Adriamycin is a first-line
chemotherapeutic agent, however, cancer cells acquire resistance to it, which is one of the …

Identification of the Brucea javanica Constituent Brusatol as a EGFR-Tyrosine Kinase Inhibitor in a Cell-Free Assay

C Suwattanasophon, A Mistlberger-Reiner… - ACS …, 2023 - ACS Publications
Inhibitors of the tyrosine kinase (TK) activity of the epidermal growth factor receptor (EGFR)
are routinely used in cancer therapy. However, there is a need to discover a new TK …