Aging is driven by hallmarks fulfilling the following three premises:(1) their age-associated
manifestation,(2) the acceleration of aging by experimentally accentuating them, and (3) the …

Short telomeres confer risk of degenerative diseases. Chronic psychological stress can lead
to disease through many pathways, and research from in vitro studies to human longitudinal …

Telomeres, the end fragments of chromosomes, play key roles in cellular proliferation and
senescence. Here we characterize the genetic architecture of naturally occurring variation in …

During fertilization, the egg and the sperm are supposed to contribute precisely one copy of
each chromosome to the embryo. However, human eggs frequently contain an incorrect …

Human telomerase is a RNA–protein complex that extends the 3′ end of linear
chromosomes by synthesizing multiple copies of the telomeric repeat TTAGGG. Its activity is …

The mammalian DNA polymerase-α–primase (Polα–primase) complex is essential for DNA
metabolism, providing the de novo RNA–DNA primer for several DNA replication pathways …

It has been known for decades that telomerase extends the 3′ end of linear eukaryotic
chromosomes and dictates the telomeric repeat sequence based on the template in its RNA …

Repetitive DNA sequences playing critical roles in driving evolution, inducing variation, and
regulating gene expression. In this review, we summarized the definition, arrangement, and …

Shelterin and nucleosomes are the key players that organize mammalian chromosome ends
into the protective telomere caps. However, how they interact with each other at telomeres …

Simple Summary Cells undergoing malignant transformation must circumvent replicative
senescence and eventual cell death associated with progressive telomere shortening that …