Left ventricular remodelling post-myocardial infarction: pathophysiology, imaging, and novel therapies

S Frantz, MJ Hundertmark… - European heart …, 2022 - academic.oup.com
Most patients survive acute myocardial infarction (MI). Yet this encouraging development
has certain drawbacks: heart failure (HF) prevalence is increasing and patients affected tend …

Cardiac MRI Endpoints in Myocardial Infarction Experimental and Clinical Trials: JACC Scientific Expert Panel

B Ibanez, AH Aletras, AE Arai, H Arheden, J Bax… - Journal of the American …, 2019 - jacc.org
After a reperfused myocardial infarction (MI), dynamic tissue changes occur (edema,
inflammation, microvascular obstruction, hemorrhage, cardiomyocyte necrosis, and …

The pathophysiology of acute myocardial infarction and strategies of protection beyond reperfusion: a continual challenge

G Heusch, BJ Gersh - European heart journal, 2017 - academic.oup.com
The incidence of ST segment elevation myocardial infarction (STEMI) has decreased over
the last two decades in developed countries, but mortality from STEMI despite widespread …

Reappraisal of ischemic heart disease: fundamental role of coronary microvascular dysfunction in the pathogenesis of angina pectoris

JC Kaski, F Crea, BJ Gersh, PG Camici - Circulation, 2018 - Am Heart Assoc
In recent years, it has become apparent that coronary microvascular dysfunction plays a
pivotal pathogenic role in angina pectoris. Functional and structural mechanisms can affect …

Novel targets and future strategies for acute cardioprotection: Position Paper of the European Society of Cardiology Working Group on Cellular Biology of the Heart

DJ Hausenloy, D Garcia-Dorado… - Cardiovascular …, 2017 - academic.oup.com
Ischaemic heart disease and the heart failure that often results, remain the leading causes of
death and disability in Europe and worldwide. As such, in order to prevent heart failure and …

Optimized treatment of ST-elevation myocardial infarction: the unmet need to target coronary microvascular obstruction as primary treatment goal to further improve …

G Niccoli, RA Montone, B Ibanez, H Thiele… - Circulation …, 2019 - Am Heart Assoc
Primary percutaneous coronary intervention is nowadays the preferred reperfusion strategy
for patients with acute ST-segment–elevation myocardial infarction, aiming at restoring …

Targeting reperfusion injury in patients with ST-segment elevation myocardial infarction: trials and tribulations

DJ Hausenloy, HE Botker, T Engstrom… - European heart …, 2017 - academic.oup.com
Ischaemic heart disease (IHD) remains the leading cause of death and disability in Europe
and worldwide. A major cause of morbidity and mortality in IHD patients is an acute ST …

Myocardial tissue characterization and fibrosis by imaging

TD Karamitsos, A Arvanitaki, H Karvounis… - Cardiovascular …, 2020 - jacc.org
Myocardial fibrosis, either focal or diffuse, is a common feature of many cardiac diseases
and is associated with a poor prognosis for major adverse cardiovascular events. Although …

Cardiovascular magnetic resonance in acute st-segment–elevation myocardial infarction: Recent advances, controversies, and future directions

H Bulluck, R Dharmakumar, AE Arai, C Berry… - Circulation, 2018 - Am Heart Assoc
Although mortality after ST-segment elevation myocardial infarction (MI) is on the decline,
the number of patients developing heart failure as a result of MI is on the rise. Apart from …

Prognostic value of myocardial scarring on CMR in patients with cardiac sarcoidosis

GC Coleman, PW Shaw, PC Balfour… - JACC: Cardiovascular …, 2017 - jacc.org
Objectives: This study sought to perform a systematic review and meta-analysis to
understand the prognostic value of myocardial scarring as evidenced by late gadolinium …