Immunological memory is a cardinal feature of adaptive immunity and an important goal of
vaccination strategies. Here we highlight advances in the understanding of the diverse T …

Investigators developed chimeric antigen receptors (CAR s) for expression on T cells more
than 25 years ago. When the CAR is derived from an antibody, the resultant cell should …

T cell receptor (TCR) signal strength is a key determinant of T cell responses. We developed
a cancer mouse model in which tumor-specific CD8 T cells (TST cells) encounter tumor …

Although recent evidence demonstrates heterogeneity among CD8+ T cells during chronic
infection, developmental relationships and mechanisms underlying their fate decisions …

Summary A naive CD4+ T cell population specific for a microbial peptide: major
histocompatibility complex II ligand (p: MHCII) typically consists of about 100 cells, each with …

During immune responses, T cells are subject to clonal competition, which leads to the
predominant expansion of high-affinity clones; however, there is little understanding of how …

T cells are critical in orchestrating protective immune responses to cancer and an array of
pathogens. The interaction between a peptide MHC (pMHC) complex on antigen presenting …

The asymmetric partitioning of fate-determining proteins has been shown to contribute to the
generation of CD8+ effector and memory T cell precursors. Here we demonstrate the …

Improving the functional avidity of effector T cells is critical in overcoming inhibitory factors
within the tumor microenvironment and eliciting tumor regression. We have found that Cish …

Upon infection, CD8+ T cells undergo a stepwise process of early activation, expansion, and
differentiation into effector cells. How these phases are transcriptionally regulated is …