Autism spectrum disorder (ASD) is a pervasive neurodevelopmental disorder characterized
by difficulties in social interaction, language development delays, repeated body …

FOXP transcription factors are an evolutionarily ancient protein subfamily coordinating the
development of several organ systems in the vertebrate body. Association of their genes …

The goal of this research was to obtain initial estimates of the prevalence of each of four
types of motor speech disorders in children with idiopathic Speech Delay (SD) and to use …

Neurons store information by changing synaptic input weights. In addition, they can adjust
their membrane excitability to alter spike output. Here, we demonstrate a role of such …

The discovery of the FOXP2 transcription factor, and its implication in a rare severe human
speech and language disorder, has led to two decades of empirical studies focused on …

Summary Forkhead box P2 (FOXP2) is a transcription factor expressed in the human brain
that peaks during fetal development, and disruption in its ability to regulate downstream …

Highlights•Rare variants disrupting speech, in genes like FOXP2, give insight into
neurobiology of key human traits.•Neural functions of FOXP2 are being studied in human …

The cerebellum is critical for controlling motor and non-motor functions via cerebellar circuit
that is composed of defined cell types, which approximately account for more than half of …

Recent advances in the genetics of neurodevelopmental disorders (NDDs) have identified
the transcription factor FOXP2 as one of numerous risk genes, eg in autism spectrum …

Mutations in the transcription factors FOXP1 and FOXP2 are associated with speech
impairments. FOXP1 is additionally linked to cognitive deficits, as is FOXP4. These FoxP …