Methods Specific studies and articles were reviewed to illustrate what the test measures, to
evaluate its sensitivity to change, and to discuss its use in clinical practice. Results The …

Objective: Suicide is a public health crisis with limited treatment options. The authors
conducted a systematic review and individual participant data meta-analysis examining the …

In the past, little or no attention was paid to cognitive disorders associated with depression
(a condition sometimes termed pseudodementia). However, recent years have seen a …

Background: The Canadian Network for Mood and Anxiety Treatments (CANMAT)
conducted a revision of the 2009 guidelines by updating the evidence and …

Objectives: To provide guidance for the management of mood disorders, based on scientific
evidence supplemented by expert clinical consensus and formulate recommendations to …

Attention is the gate through which sensory information enters our conscious experiences.
Oftentimes, patients with major depressive disorder (MDD) complain of concentration …

Background Many depressed patients are not able to achieve or sustain symptom remission
despite serial treatment trials–often termed “treatment resistant depression”. A broader …

Randomized trials have shown that selective serotonin reuptake inhibitors (SSRIs) and
serotonin-norepinephrine reuptake inhibitors (SNRIs) have better safety profiles than …

Background: Cognitive dysfunction is often present in major depressive disorder (MDD).
Several clinical trials have noted a pro-cognitive effect of antidepressants in MDD. The …

Cognitive dysfunction is a symptomatic domain identified across many mental disorders.
Cognitive deficits in individuals with major depressive disorder (MDD) contribute …