Anhedonia—the loss of pleasure or lack of reactivity to pleasurable stimuli—remains a
formidable treatment challenge across neuropsychiatric disorders. In major depressive …

As one of most common and severe mental disorders, major depressive disorder (MDD)
significantly increases the risks of premature death and other medical conditions for patients …

What changes in brain function cause the debilitating symptoms of depression? Can we use
the answers to this question to invent more effective, faster acting antidepressant drug …

Background As the disorder progresses, patients with depression suffer from decreased
emotional stability, cognitive control and motivation. In the present study, we examined the …

Deficits in reward processing are a central feature of major depressive disorder with patients
exhibiting decreased reward learning and altered feedback sensitivity in probabilistic …

The Wistar Kyoto (WKY) rat has been proposed as a model of depression-like symptoms.
However, anhedonia—a reduction in the response to normatively rewarding events—as a …

Chronic stress is a known risk factor for the development of major depression (MDD) and is
commonly used to induce a depression-like phenotype in rodents. Similar phenotypic effects …

Chronic pain is highly comorbid with affective disorders, including major depressive
disorder. A core feature of major depressive disorder is a loss of interest in previously …

Cognitive biases can arise from cognitive processing under affective states and reflect the
impact of emotion on cognition. In animal studies, the existing methods for detecting animal …

Until now, depression research has taken a surprisingly narrow approach to modelling the
disease, mainly focusing on some form of psychomotor retardation within a mechanistic …