Ropivacaine: a review of its use in regional anaesthesia and acute pain management

D Simpson, MP Curran, V Oldfield, GM Keating - Drugs, 2005 - Springer
Ropivacaine (Naropin®) is the pure S (−)-enantiomer of propivacaine, and is a long-acting
amide local anaesthetic agent, eliciting nerve block via reversible inhibition of sodium ion …

The importance of stereoselective determination of drugs in the clinical laboratory

KM Rentsch - Journal of biochemical and biophysical methods, 2002 - Elsevier
About 56% of the drugs currently in use are chiral compounds, and 88% of these chiral
synthetic drugs are used therapeutically as racemates. Only a few of these drugs qualify for …

规模化分娩镇痛的可行性

曲元, 吴新民, 赵国立, 王薇, 张峥, 刘源, 陈小云 - 中华麻醉学杂志, 2003 - cqvip.com
目的评价规模化开展分娩镇痛的可行性. 方法自愿接受分娩镇痛及无产科及麻醉禁忌证的足月孕
初产妇819 例, 全部采用腰麻-硬膜外联合镇痛(CESA) 和病人自控镇痛(PCEA) 的分娩镇痛法 …

A multimodal analgesia protocol for total knee arthroplasty: a randomized, controlled study

PA Vendittoli, P Makinen, P Drolet, M Lavigne… - JBJS, 2006 - journals.lww.com
Background: Although numerous methods of postoperative analgesia have been
investigated in an attempt to improve pain control after total knee arthroplasty, parenteral …

[HTML][HTML] Comparative evaluation of dexmedetomidine and fentanyl for epidural analgesia in lower limb orthopedic surgeries

SJS Bajwa, V Arora, J Kaur, A Singh… - Saudi journal of …, 2011 - journals.lww.com
Methods: A total of one hundred patients of both gender aged 21-56 years, American
Society of Anaesthesiologist (ASA) physical status I and II who underwent lower limb …

Ropivacaine: a pharmacological review

TG Hansen - Expert review of neurotherapeutics, 2004 - Taylor & Francis
Ropivacaine (Naropin®, AstraZeneca) a new long-acting amide local anaesthetic agent, is a
pure S-enantiomer, with a high pKa and relatively low-lipid solubility. Since its clinical …

Toxicity of local anaesthetics

B Cox, ME Durieux, MAE Marcus - Best practice & research Clinical …, 2003 - Elsevier
The complications of failure, neural injury and local anaesthetic toxicity are common to all
regional anaesthetic techniques, and individual techniques are associated with specific …

The central nervous system and cardiovascular effects of levobupivacaine and ropivacaine in healthy volunteers

J Stewart, N Kellett, D Castro - Anesthesia & Analgesia, 2003 - journals.lww.com
IMPLICATIONS: This study compared directly, for the first time, the toxicity of
levobupivacaine and ropivacaine in healthy volunteers. Levobupivacaine and ropivacaine …

A pH‐Responsive Core‐Shell Microneedle Patch with Self‐Monitoring Capability for Local Long‐Lasting Analgesia

A Zhang, Y Zeng, B Xiong, X Jiang, Y Jin… - Advanced Functional …, 2024 - Wiley Online Library
Postoperative pain, as a common and significant healthcare issue, has always been the
focus of attention in the field of anesthesia for its control and treatment. In the present study …

Spinal anaesthesia: comparison of plain ropivacaine 5 mg ml–1 with bupivacaine 5 mg ml–1 for major orthopaedic surgery

DA McNamee, AM McClelland, S Scott… - British journal of …, 2002 - academic.oup.com
Background. Ropivacaine provides effective spinal anaesthesia for total hip arthroplasty.
This study was designed to compare the efficacy and safety of plain ropivacaine with plain …