Thinking outside the box: non-canonical targets in multiple sclerosis
L Bierhansl, HP Hartung, O Aktas, T Ruck… - Nature reviews Drug …, 2022 - nature.com
Multiple sclerosis (MS) is an immune-mediated disease of the central nervous system that
causes demyelination, axonal degeneration and astrogliosis, resulting in progressive …
causes demyelination, axonal degeneration and astrogliosis, resulting in progressive …
The multiple sclerosis prodrome
N Makhani, H Tremlett - Nature Reviews Neurology, 2021 - nature.com
A prodrome is an early set of signs, symptoms or other findings that occur before the onset of
typical symptoms of a disease. Prodromal phases are well recognized in several …
typical symptoms of a disease. Prodromal phases are well recognized in several …
Longitudinal analysis reveals high prevalence of Epstein-Barr virus associated with multiple sclerosis
Multiple sclerosis (MS) is a chronic inflammatory demyelinating disease of the central
nervous system of unknown etiology. We tested the hypothesis that MS is caused by Epstein …
nervous system of unknown etiology. We tested the hypothesis that MS is caused by Epstein …
What can we learn from sex differences in MS?
PK Coyle - Journal of personalized medicine, 2021 - mdpi.com
Multiple sclerosis (MS) is the major acquired central nervous system disease of young
adults. It is a female predominant disease. Multiple aspects of MS are influenced by sex …
adults. It is a female predominant disease. Multiple aspects of MS are influenced by sex …
Risk factors and time to clinical symptoms of multiple sclerosis among patients with radiologically isolated syndrome
C Lebrun-Frénay, F Rollot, L Mondot… - JAMA Network …, 2021 - jamanetwork.com
Importance Younger age, oligoclonal bands, and infratentorial and spinal cord lesions are
factors associated with an increased 10-year risk of clinical conversion from radiologically …
factors associated with an increased 10-year risk of clinical conversion from radiologically …
The gut microbiota in pediatric multiple sclerosis and demyelinating syndromes
Objective To examine the gut microbiota in individuals with and without pediatric‐onset
multiple sclerosis (MS). Methods We compared stool‐derived microbiota of Canadian …
multiple sclerosis (MS). Methods We compared stool‐derived microbiota of Canadian …
An autoantibody signature predictive for multiple sclerosis
Although B cells are implicated in multiple sclerosis (MS) pathophysiology, a predictive or
diagnostic autoantibody remains elusive. In this study, the Department of Defense Serum …
diagnostic autoantibody remains elusive. In this study, the Department of Defense Serum …
The multiple sclerosis prodrome: evidence to action
H Tremlett, KL Munger, N Makhani - Frontiers in Neurology, 2022 - frontiersin.org
A growing body of work points toward the existence of a clinically symptomatic prodromal
phase in multiple sclerosis (MS) that might span 5–10 years or more. A prodrome is an early …
phase in multiple sclerosis (MS) that might span 5–10 years or more. A prodrome is an early …
Association of infectious mononucleosis in childhood and adolescence with risk for a subsequent multiple sclerosis diagnosis among siblings
Y Xu, A Hiyoshi, KA Smith, F Piehl, T Olsson… - JAMA Network …, 2021 - jamanetwork.com
Importance Epstein-Barr virus and its acute manifestation, infectious mononucleosis (IM),
are associated with an increased risk of multiple sclerosis (MS). Whether this association is …
are associated with an increased risk of multiple sclerosis (MS). Whether this association is …
Psychiatric comorbidity during the prodromal period in patients with multiple sclerosis
AS Chertcoff, FLA Yusuf, F Zhu, C Evans, JD Fisk… - Neurology, 2023 - AAN Enterprises
Background and Objectives Psychiatric morbidity is common after a multiple sclerosis (MS)
diagnosis. However, little is known about psychiatric comorbidity during the prodromal …
diagnosis. However, little is known about psychiatric comorbidity during the prodromal …