Thinking outside the box: non-canonical targets in multiple sclerosis

L Bierhansl, HP Hartung, O Aktas, T Ruck… - Nature reviews Drug …, 2022 - nature.com
Multiple sclerosis (MS) is an immune-mediated disease of the central nervous system that
causes demyelination, axonal degeneration and astrogliosis, resulting in progressive …

The multiple sclerosis prodrome

N Makhani, H Tremlett - Nature Reviews Neurology, 2021 - nature.com
A prodrome is an early set of signs, symptoms or other findings that occur before the onset of
typical symptoms of a disease. Prodromal phases are well recognized in several …

Longitudinal analysis reveals high prevalence of Epstein-Barr virus associated with multiple sclerosis

K Bjornevik, M Cortese, BC Healy, J Kuhle, MJ Mina… - Science, 2022 - science.org
Multiple sclerosis (MS) is a chronic inflammatory demyelinating disease of the central
nervous system of unknown etiology. We tested the hypothesis that MS is caused by Epstein …

What can we learn from sex differences in MS?

PK Coyle - Journal of personalized medicine, 2021 - mdpi.com
Multiple sclerosis (MS) is the major acquired central nervous system disease of young
adults. It is a female predominant disease. Multiple aspects of MS are influenced by sex …

Risk factors and time to clinical symptoms of multiple sclerosis among patients with radiologically isolated syndrome

C Lebrun-Frénay, F Rollot, L Mondot… - JAMA Network …, 2021 - jamanetwork.com
Importance Younger age, oligoclonal bands, and infratentorial and spinal cord lesions are
factors associated with an increased 10-year risk of clinical conversion from radiologically …

The gut microbiota in pediatric multiple sclerosis and demyelinating syndromes

H Tremlett, F Zhu, D Arnold, A Bar‐Or… - Annals of clinical …, 2021 - Wiley Online Library
Objective To examine the gut microbiota in individuals with and without pediatric‐onset
multiple sclerosis (MS). Methods We compared stool‐derived microbiota of Canadian …

An autoantibody signature predictive for multiple sclerosis

CR Zamecnik, GM Sowa, A Abdelhak, R Dandekar… - Nature Medicine, 2024 - nature.com
Although B cells are implicated in multiple sclerosis (MS) pathophysiology, a predictive or
diagnostic autoantibody remains elusive. In this study, the Department of Defense Serum …

The multiple sclerosis prodrome: evidence to action

H Tremlett, KL Munger, N Makhani - Frontiers in Neurology, 2022 - frontiersin.org
A growing body of work points toward the existence of a clinically symptomatic prodromal
phase in multiple sclerosis (MS) that might span 5–10 years or more. A prodrome is an early …

Association of infectious mononucleosis in childhood and adolescence with risk for a subsequent multiple sclerosis diagnosis among siblings

Y Xu, A Hiyoshi, KA Smith, F Piehl, T Olsson… - JAMA Network …, 2021 - jamanetwork.com
Importance Epstein-Barr virus and its acute manifestation, infectious mononucleosis (IM),
are associated with an increased risk of multiple sclerosis (MS). Whether this association is …

Psychiatric comorbidity during the prodromal period in patients with multiple sclerosis

AS Chertcoff, FLA Yusuf, F Zhu, C Evans, JD Fisk… - Neurology, 2023 - AAN Enterprises
Background and Objectives Psychiatric morbidity is common after a multiple sclerosis (MS)
diagnosis. However, little is known about psychiatric comorbidity during the prodromal …