Lung lipid metabolism participates both in infant and adult pulmonary disease. The lung is
composed by multiple cell types with specialized functions and coordinately acting to meet …

The respiratory surface in the mammalian lung is stabilized by pulmonary surfactant, a
membrane-based system composed of multiple lipids and specific proteins, the primary …

The growth and differentiation factor transforming growth factor-β2 (TGFβ2) is thought to play
important roles in multiple developmental processes. Targeted disruption of the TGF β2 …

Interstitial lung diseases are a heterogeneous group of disorders that are poorly understood
at a molecular level. 1, 2 The cause is often unknown, and the histologic diagnoses used in …

In acquired pulmonary alveolar proteinosis, lipids and proteins accumulate within the alveoli
because alveolar macrophages cannot catabolize surfactants. Surprisingly, alveolar …

Pulmonary surfactant is an essential lipid–protein complex to maintain an operative
respiratory surface at the mammalian lungs. It reduces surface tension at the alveolar air …

The pulmonary surfactant system constitutes an excellent example of how dynamic
membrane polymorphism governs some biological functions through specific lipid–lipid …

The alveolar region of the lung creates an extensive epithelial surface that mediates the
transfer of oxygen and carbon dioxide required for respiration after birth. Maintenance of …

Pulmonary surfactant is essential for life and is composed of a complex lipoprotein-like
mixture that lines the inner surface of the lung to prevent alveolar collapse at the end of …

Pulmonary surfactants consist of phospholipids and the hydrophobic proteins surfactant
protein B and surfactant protein C. These surfactants keep the alveoli in the lung open to the …