Background Significant pain can be experienced after laparoscopic cholecystectomy. This
systematic review aims to formulate PROSPECT (PROcedure SPECific Postoperative Pain …

This article discusses recent evidence from the peer-reviewed literature regarding the role of
local anesthetics, NSAIDs, gabapentinoids, and acetaminophen, as well as alpha-2 …

To improve postoperative pain management, several concepts have been developed,
including preemptive analgesia, preventive analgesia, and multimodal analgesia. This …

Opioids are a key risk factor for postoperative nausea and vomiting (PONV). As intravenous
(iv) acetaminophen reduces postoperative pain and opioid requirements, one would expect …

Surgical care episodes place opioid-naïve patients at risk for transitioning to new persistent
postoperative opioid use. With one of the central principles being the application of …

Multimodal analgesia captures the effectiveness of individual agents in optimal dosages that
maximize efficacy and attempts to minimize side effects from one analgesic. This important …

Acetaminophen was first used clinically in 1887 but only much later—during the mid-1950s—
was it widely marketed in the United States. 1 It has since gone on to become one of the …

Objectives: The effect of a single-dose systemic acetaminophen to treat postoperative pain
has been previously quantified, but the effect of systemic acetaminophen to prevent …

Methods: A total of 120 patients were included in this prospective, double-blind, randomised
study. Patients were randomly divided into three equal sized (n= 40) study groups. Patients …

Background While laparoscopic cholecystectomy is generally considered less painful than
open surgery, pain is one of the important reasons for delayed discharge after day‐surgery …