Synthesizing the evidence for ketamine and esketamine in treatment-resistant depression: an international expert opinion on the available evidence and …
RS McIntyre, JD Rosenblat… - American Journal of …, 2021 - Am Psychiatric Assoc
Replicated international studies have underscored the human and societal costs associated
with major depressive disorder. Despite the proven efficacy of monoamine-based …
with major depressive disorder. Despite the proven efficacy of monoamine-based …
Ketamine and ketamine metabolite pharmacology: insights into therapeutic mechanisms
Ketamine, a racemic mixture consisting of (S)-and (R)-ketamine, has been in clinical use
since 1970. Although best characterized for its dissociative anesthetic properties, ketamine …
since 1970. Although best characterized for its dissociative anesthetic properties, ketamine …
Single, repeated, and maintenance ketamine infusions for treatment-resistant depression: a randomized controlled trial
JL Phillips, S Norris, J Talbot… - American Journal of …, 2019 - Am Psychiatric Assoc
Objective: Subanesthetic ketamine doses have been shown to have rapid yet transient
antidepressant effects in patients with treatment-resistant depression, which may be …
antidepressant effects in patients with treatment-resistant depression, which may be …
Psychedelics in psychiatry: neuroplastic, immunomodulatory, and neurotransmitter mechanisms
Mounting evidence suggests safety and efficacy of psychedelic compounds as potential
novel therapeutics in psychiatry. Ketamine has been approved by the Food and Drug …
novel therapeutics in psychiatry. Ketamine has been approved by the Food and Drug …
Real-world effectiveness of ketamine in treatment-resistant depression: A systematic review & meta-analysis
Ketamine is a promising therapeutic option in treatment-resistant depression (TRD). The
acute efficacy of ketamine in TRD has been demonstrated in replicated randomised …
acute efficacy of ketamine in TRD has been demonstrated in replicated randomised …
Side-effects associated with ketamine use in depression: a systematic review
B Short, J Fong, V Galvez, W Shelker… - The Lancet Psychiatry, 2018 - thelancet.com
This is the first systematic review of the safety of ketamine in the treatment of depression
after single and repeated doses. We searched MEDLINE, PubMed, PsycINFO, and …
after single and repeated doses. We searched MEDLINE, PubMed, PsycINFO, and …
Targeting glutamate signalling in depression: progress and prospects
Major depressive disorder (MDD) is severely disabling, and current treatments have limited
efficacy. The glutamate N-methyl-d-aspartate receptor (NMDAR) antagonist ketamine was …
efficacy. The glutamate N-methyl-d-aspartate receptor (NMDAR) antagonist ketamine was …
A consensus statement on the use of ketamine in the treatment of mood disorders
G Sanacora, MA Frye, W McDonald, SJ Mathew… - JAMA …, 2017 - jamanetwork.com
Importance Several studies now provide evidence of ketamine hydrochloride's ability to
produce rapid and robust antidepressant effects in patients with mood and anxiety disorders …
produce rapid and robust antidepressant effects in patients with mood and anxiety disorders …
The acute antisuicidal effects of single-dose intravenous ketamine and intranasal esketamine in individuals with major depression and bipolar disorders: a systematic …
The efficacy of ketamine in reducing suicidal ideation (SI) has been previously reported. We
aimed to evaluate acute anti-SI effects of single-dose ketamine in different …
aimed to evaluate acute anti-SI effects of single-dose ketamine in different …
[HTML][HTML] Efficacy of single and repeated administration of ketamine in unipolar and bipolar depression: a meta-analysis of randomized clinical trials
Background Due to unmet clinical needs for efficient drugs with a rapid onset of
antidepressant effects, we aimed to evaluate the efficacy of single-dose ketamine in different …
antidepressant effects, we aimed to evaluate the efficacy of single-dose ketamine in different …