The p53 tumor-suppressor plays a critical role in the prevention of human cancer. In the
absence of cellular stress, the p53 protein is maintained at low steady-state levels and …

The role of p53 as a central mediator of the DNA damage and other cellular stress
responses is well established. The ultimate growth-suppressive function of p53 in part …

MDM2 and MDMX, negative regulators of the tumor suppressor p53, can work separately
and as a heteromeric complex to restrain p53's functions. MDM2 also has pro-oncogenic …

Inherited and acquired changes in pre-mRNA splicing have been documented to play a
significant role in human disease development and many cancer-associated genes are …

ABSTRACT Hydrogen sulfide (H2S), produced by commensal sulfate‐reducing bacteria, is
an environmental insult that potentially contributes to chronic intestinal epithelial disorders …

Histone modifications play a pivotal role in regulating transcription and other chromatin-
associated processes. In yeast, histone H2B monoubiquitylation affects gene silencing …

Hu antigen R (HuR) is a central RNA‐binding protein regulating cell dedifferentiation,
proliferation, and survival, which are well‐established hallmarks of cancer. HuR is frequently …

Abstract We recently isolated 20 (S)-25-methoxyl-dammarane-3β, 12β, 20-triol (25-OCH 3-
PPD), a natural product from Panax notoginseng, and demonstrated its cytotoxicity against a …

The protein (MDM2) coded by the mouse double minute-2 (mdm2) gene or its human
homologue is well known as an oncoprotein. Malignant human tumors particularly breast …

Cancer cells with p53 mutations, in general, grow more aggressively than those with wild-
type p53 and show “gain of function”(GOF) phenotypes such as increased growth rate …