Simple Summary Over 40% of patients with colorectal cancer will develop liver metastases
during the course of their disease. While resectable liver-limited colorectal liver metastases …

Objective The aim of this review was to investigate whether the best-studied somatic
mutations impact surgical management of CRLM by informing:(I) post-hepatectomy …

Background RAS mutation status is considered a powerful prognostic factor in patients
undergoing hepatectomy for colorectal liver metastases (CLM). However, whether its …

Introduction Two novel clinical risk scores (CRS) that incorporate KRAS mutation status
were developed: modified CRS (mCRS) and GAME score. However, they have not been …

Background Currently, surgical resection is the mainstay for colorectal liver metastases
(CRLM) management and the only potentially curative treatment modality. Prognostication …

Purpose: The incidence of early-onset CRC is increasing. However, the effect of age of
onset on the long-term outcome of colorectal cancer liver metastasis (CRLM) remains …

Recurrence and survival vary widely among patients who undergo curative-intent resection
of colorectal liver metastases (CRLM). Prognostic models provide estimated probabilities of …

Background The prognostic predictive tool for patients with colorectal liver metastasis
(CRLM) is limited and the criteria for administering preoperative neoadjuvant chemotherapy …

Background There is still debate regarding the principal role and ideal timing of
perioperative chemotherapy (CTx) for patients with upfront resectable colorectal liver …

Background Prognostic stratification of patients with colorectal cancer liver metastasis based
solely on tumor-related factors has only moderate discriminatory ability. We hypothesized …