Immunogenicity of lipid nanoparticles and its impact on the efficacy of mRNA vaccines and therapeutics
Several studies have utilized a lipid nanoparticle delivery system to enhance the
effectiveness of mRNA therapeutics and vaccines. However, these nanoparticles are …
effectiveness of mRNA therapeutics and vaccines. However, these nanoparticles are …
Lipid nanoparticles (LNPs) for in vivo RNA delivery and their breakthrough technology for future applications
RNA therapeutics show a significant breakthrough for the treatment of otherwise incurable
diseases and genetic disorders by regulating disease-related gene expression. The …
diseases and genetic disorders by regulating disease-related gene expression. The …
Lipid-based nanoparticles for drug/gene delivery: An overview of the production techniques and difficulties encountered in their industrial development
Over the past decade, the therapeutic potential of nanomaterials as novel drug delivery
systems complementing conventional pharmacology has been widely acknowledged …
systems complementing conventional pharmacology has been widely acknowledged …
Strategies to reduce the risks of mRNA drug and vaccine toxicity
D Bitounis, E Jacquinet, MA Rogers… - Nature Reviews Drug …, 2024 - nature.com
Abstract mRNA formulated with lipid nanoparticles is a transformative technology that has
enabled the rapid development and administration of billions of coronavirus disease 2019 …
enabled the rapid development and administration of billions of coronavirus disease 2019 …
Lipid Nanoparticle-Mediated Hit-and-Run Approaches Yield Efficient and Safe In Situ Gene Editing in Human Skin
J Bolsoni, D Liu, F Mohabatpour, R Ebner… - ACS …, 2023 - ACS Publications
Despite exciting advances in gene editing, the efficient delivery of genetic tools to
extrahepatic tissues remains challenging. This holds particularly true for the skin, which …
extrahepatic tissues remains challenging. This holds particularly true for the skin, which …
Lipid nanoparticles optimized for targeting and release of nucleic acid
Y Jia, X Wang, L Li, F Li, J Zhang… - Advanced Materials, 2024 - Wiley Online Library
Lipid nanoparticles (LNPs) are currently the most promising clinical nucleic acids drug
delivery vehicles. LNPs prevent the degradation of cargo nucleic acids during blood …
delivery vehicles. LNPs prevent the degradation of cargo nucleic acids during blood …
Biotechnology: overcoming biological barriers to nucleic acid delivery using lipid nanoparticles
The promise of therapeutic nucleic acids has long been tempered by difficulty in overcoming
biological barriers to their delivery. The past two decades have seen the development of …
biological barriers to their delivery. The past two decades have seen the development of …
[HTML][HTML] Bile acid-containing lipid nanoparticles enhance extrahepatic mRNA delivery
Lipid nanoparticles (LNPs) have emerged as a viable, clinically-validated platform for the
delivery of mRNA therapeutics. LNPs have been utilized as mRNA delivery systems for …
delivery of mRNA therapeutics. LNPs have been utilized as mRNA delivery systems for …
Unleashing the potential: Designing antibody-targeted lipid nanoparticles for industrial applications with CMC considerations and clinical outlook
S Wang, H Wang, A Drabek, WS Smith… - Molecular …, 2023 - ACS Publications
Antibody-targeted lipid nanoparticles (Ab-LNPs) are rapidly gaining traction as multifaceted
platforms in precision medicine, adept at delivering a diverse array of therapeutic agents …
platforms in precision medicine, adept at delivering a diverse array of therapeutic agents …
Probing Molecular Packing of Lipid Nanoparticles from 31P Solution and Solid-State NMR
Lipid nanoparticles (LNPs) are intricate multicomponent systems widely recognized for their
efficient delivery of oligonucleotide cargo to host cells. Gaining insights into the molecular …
efficient delivery of oligonucleotide cargo to host cells. Gaining insights into the molecular …