Immunogenicity of lipid nanoparticles and its impact on the efficacy of mRNA vaccines and therapeutics

Y Lee, M Jeong, J Park, H Jung, H Lee - Experimental & Molecular …, 2023 - nature.com
Several studies have utilized a lipid nanoparticle delivery system to enhance the
effectiveness of mRNA therapeutics and vaccines. However, these nanoparticles are …

Lipid nanoparticles (LNPs) for in vivo RNA delivery and their breakthrough technology for future applications

M Jeong, Y Lee, J Park, H Jung, H Lee - Advanced drug delivery reviews, 2023 - Elsevier
RNA therapeutics show a significant breakthrough for the treatment of otherwise incurable
diseases and genetic disorders by regulating disease-related gene expression. The …

Lipid-based nanoparticles for drug/gene delivery: An overview of the production techniques and difficulties encountered in their industrial development

M Mehta, TA Bui, X Yang, Y Aksoy, EM Goldys… - ACS Materials …, 2023 - ACS Publications
Over the past decade, the therapeutic potential of nanomaterials as novel drug delivery
systems complementing conventional pharmacology has been widely acknowledged …

Strategies to reduce the risks of mRNA drug and vaccine toxicity

D Bitounis, E Jacquinet, MA Rogers… - Nature Reviews Drug …, 2024 - nature.com
Abstract mRNA formulated with lipid nanoparticles is a transformative technology that has
enabled the rapid development and administration of billions of coronavirus disease 2019 …

Lipid Nanoparticle-Mediated Hit-and-Run Approaches Yield Efficient and Safe In Situ Gene Editing in Human Skin

J Bolsoni, D Liu, F Mohabatpour, R Ebner… - ACS …, 2023 - ACS Publications
Despite exciting advances in gene editing, the efficient delivery of genetic tools to
extrahepatic tissues remains challenging. This holds particularly true for the skin, which …

Lipid nanoparticles optimized for targeting and release of nucleic acid

Y Jia, X Wang, L Li, F Li, J Zhang… - Advanced Materials, 2024 - Wiley Online Library
Lipid nanoparticles (LNPs) are currently the most promising clinical nucleic acids drug
delivery vehicles. LNPs prevent the degradation of cargo nucleic acids during blood …

Biotechnology: overcoming biological barriers to nucleic acid delivery using lipid nanoparticles

AG Hamilton, KL Swingle, MJ Mitchell - PLoS Biology, 2023 - journals.plos.org
The promise of therapeutic nucleic acids has long been tempered by difficulty in overcoming
biological barriers to their delivery. The past two decades have seen the development of …

[HTML][HTML] Bile acid-containing lipid nanoparticles enhance extrahepatic mRNA delivery

SK Patel, MM Billingsley, AJ Mukalel, AS Thatte… - Theranostics, 2024 - ncbi.nlm.nih.gov
Lipid nanoparticles (LNPs) have emerged as a viable, clinically-validated platform for the
delivery of mRNA therapeutics. LNPs have been utilized as mRNA delivery systems for …

Unleashing the potential: Designing antibody-targeted lipid nanoparticles for industrial applications with CMC considerations and clinical outlook

S Wang, H Wang, A Drabek, WS Smith… - Molecular …, 2023 - ACS Publications
Antibody-targeted lipid nanoparticles (Ab-LNPs) are rapidly gaining traction as multifaceted
platforms in precision medicine, adept at delivering a diverse array of therapeutic agents …

Probing Molecular Packing of Lipid Nanoparticles from 31P Solution and Solid-State NMR

R Schroder, PJ Dorsey, J Vanderburgh, W Xu… - Analytical …, 2024 - ACS Publications
Lipid nanoparticles (LNPs) are intricate multicomponent systems widely recognized for their
efficient delivery of oligonucleotide cargo to host cells. Gaining insights into the molecular …