Chemokine signaling plays an important role in the postischemic inflammatory response.
Overlapping pathways involving reactive oxygen intermediates, Toll-like receptor (TLR) …

The heart contains a population of resident macrophages that markedly expands following
injury through recruitment of monocytes and through proliferation of macrophages. In …

Regulatory T cells (Tregs) play a pivotal role in suppressing immune responses regulating
behavior and gene expression in effector T cells, macrophages, and dendritic cells. Tregs …

Myocardial fibrosis is an integral component of most cardiac pathologic conditions and
contributes to the development of both systolic and diastolic dysfunction. Because of the …

In the infarcted myocardium, necrotic cardiomyocytes release danger signals, activating an
intense inflammatory response. Inflammatory pathways play a crucial role in regulation of a …

Myocardial infarction triggers an inflammatory cascade that results in healing and
replacement of the damaged tissue with scar. Cardiomyocyte necrosis triggers innate …

The pathogenesis of acute myocardial infarction is known to be mediated by systemic,
intraplaque and myocardial inflammatory processes. Among different immune cell subsets …

Understanding the role of fibroblasts in pathologic conditions is hampered by the absence of
specific markers. Fibroblast-specific protein (FSP) 1 has been suggested as a fibroblast …

Background—Cardiac interstitial fibrosis plays an important role in the pathogenesis of
ischemic cardiomyopathy, contributing to systolic and diastolic dysfunction. We have …

Background—Matricellular proteins are extracellular matrix proteins that do not contribute
directly to tissue integrity but are capable of modulating cell function. We hypothesized that …