Premature ovarian insufficiency: a review on the role of oxidative stress and the application of antioxidants

YQ Shi, XT Zhu, SN Zhang, YF Ma, YH Han… - Frontiers in …, 2023 - frontiersin.org
Normal levels of reactive oxygen species (ROS) play an important role in regulating follicular
growth, angiogenesis and sex hormone synthesis in ovarian tissue. When the balance …

Role of the Nrf2 Signaling Pathway in Ovarian Aging: Potential Mechanism and Protective Strategies

X Gao, B Wang, Y Huang, M Wu, Y Li, Y Li… - International Journal of …, 2023 - mdpi.com
The ovary holds a significant role as a reproductive endocrine organ in women, and its
aging process bears implications such as menopause, decreased fertility, and long-term …

Diminished Ovarian Reserve in Endometriosis: Insights from In Vitro, In Vivo, and Human Studies—A Systematic Review

Z Tan, X Gong, CC Wang, T Zhang… - International Journal of …, 2023 - mdpi.com
Endometriosis, a prevalent disorder in women of reproductive age, is often associated with
undesired infertility. Ovarian reserve, an essential measure of ovarian function that is crucial …

Pyridoxamine protects human granulosa cells against advanced glycation end-products-induced steroidogenesis disturbances

M Mirani, S Bahmanpour, F Masjedi… - Molecular Biology …, 2023 - Springer
Background Ovarian advanced glycation end-products (AGEs) accumulation is associated
with ovarian granulosa cells (GCs) dysfunction. Vitamin B6 derivatives positively affected …

Integration of multi-modal datasets to estimate human aging

R Ribeiro, A Moraes, M Moreno, PG Ferreira - Machine Learning, 2024 - Springer
Aging involves complex biological processes leading to the decline of living organisms. As
population lifespan increases worldwide, the importance of identifying factors underlying …

Dynamics of serum exosome microRNA profile altered by chemically induced estropause and rescued by estrogen therapy in female mice

BM Zanini, BM de Avila, DN Garcia, JD Hense… - GeroScience, 2024 - Springer
The decline in the ovarian reserve leads to menopause and reduced serum estrogens.
MicroRNAs are small non-coding RNAs, which can regulate gene expression and be …

[HTML][HTML] Targeting organ-specific mitochondrial dysfunction to improve biological aging

CT Madreiter-Sokolowski, U Hiden, J Krstic… - Pharmacology & …, 2024 - Elsevier
In an aging society, unveiling new anti-aging strategies to prevent and combat aging-related
diseases is of utmost importance. Mitochondria are the primary ATP production sites and key …

Understanding the mechanisms of diminished Ovarian Reserve: insights from genetic variants and Regulatory factors

Q Zhu, H Ma, J Wang, X Liang - Reproductive Sciences, 2024 - Springer
Delaying childbearing age has become a trend in modern times, but it has also led to a
common challenge in clinical reproductive medicine—diminished ovarian reserve (DOR) …

[HTML][HTML] Autophagy and Female Fertility: Mechanisms, Clinical Implications, and Emerging Therapies

AH Harrath, MA Rahman, SK Bhajan, AK Bishwas… - Cells, 2024 - mdpi.com
Autophagy, an evolutionarily conserved cellular mechanism essential for maintaining
internal stability, plays a crucial function in female reproductive ability. In this review, we …

Dual-Activated H2O2-Responsive AIE Probes for Oocyte Quality Assessment

X Dong, H Ouyang, X Lou, F Xia, L Jin… - Analytical …, 2024 - ACS Publications
Nonobstructive azoospermia (NOA) is an important cause of infertility, and intracytoplasmic
sperm injection (ICSI) is the mainstay of treatment for these patients. In cases where a …