In Vivo Organic Bioelectronics for Neuromodulation
The nervous system poses a grand challenge for integration with modern electronics and
the subsequent advances in neurobiology, neuroprosthetics, and therapy which would …
the subsequent advances in neurobiology, neuroprosthetics, and therapy which would …
[HTML][HTML] Neural tissue engineering with structured hydrogels in CNS models and therapies
The development of techniques to create and use multiphase microstructured hydrogels
(granular hydrogels or microgels) has enabled the generation of cultures with more …
(granular hydrogels or microgels) has enabled the generation of cultures with more …
Applications of human brain organoids to clinical problems
Brain organoids are an exciting new technology with the potential to significantly change
how diseases of the brain are understood and treated. These three‐dimensional neural …
how diseases of the brain are understood and treated. These three‐dimensional neural …
[HTML][HTML] Innervation: the missing link for biofabricated tissues and organs
S Das, WJ Gordián-Vélez, HC Ledebur… - NPJ Regenerative …, 2020 - nature.com
Innervation plays a pivotal role as a driver of tissue and organ development as well as a
means for their functional control and modulation. Therefore, innervation should be carefully …
means for their functional control and modulation. Therefore, innervation should be carefully …
Recent trends in the development of peptide and protein-based hydrogel therapeutics for the healing of CNS injury
Traumatic brain injury (TBI) and spinal cord injury (SCI) cause millions of deaths and
permanent or prolonged physical disabilities around the globe every year. It generally …
permanent or prolonged physical disabilities around the globe every year. It generally …
[HTML][HTML] Emerging regenerative medicine and tissue engineering strategies for Parkinson's disease
JP Harris, JC Burrell, LA Struzyna, HI Chen… - npj Parkinson's …, 2020 - nature.com
Parkinson's disease (PD) is the second most common progressive neurodegenerative
disease, affecting 1–2% of people over 65. The classic motor symptoms of PD result from …
disease, affecting 1–2% of people over 65. The classic motor symptoms of PD result from …
[HTML][HTML] Dysregulation of BRD4 function underlies the functional abnormalities of MeCP2 mutant neurons
Rett syndrome (RTT), mainly caused by mutations in methyl-CpG binding protein 2
(MeCP2), is one of the most prevalent intellectual disorders without effective therapies. Here …
(MeCP2), is one of the most prevalent intellectual disorders without effective therapies. Here …
[HTML][HTML] Biohybrid neural interfaces: improving the biological integration of neural implants
Implantable neural interfaces (NIs) have emerged in the clinic as outstanding tools for the
management of a variety of neurological conditions caused by trauma or disease. However …
management of a variety of neurological conditions caused by trauma or disease. However …
Electrical stimulation induced structural 3D human engineered neural tissue with well-developed neuronal network and functional connectivity
X Meng, X Yu, Y Lu, Z Pei, G Wang, M Qi… - Journal of Neural …, 2023 - iopscience.iop.org
Objective. Three-dimensional (3D) neural tissue engineering is expected to provide new
stride in developing neural disease models and functional substitutes to aid in the treatment …
stride in developing neural disease models and functional substitutes to aid in the treatment …
Transplantable living scaffolds comprised of micro-tissue engineered aligned astrocyte networks to facilitate central nervous system regeneration
Neurotrauma, stroke, and neurodegenerative disease may result in widespread loss of
neural cells as well as the complex interconnectivity necessary for proper central nervous …
neural cells as well as the complex interconnectivity necessary for proper central nervous …