Background Chromatin accessibility is crucial for gene expression regulation in specific cells
and in multiple biological processes. Assay for Transposase Accessible Chromatin with high …

Recent development of human three-dimensional organoid cultures has opened new doors
and opportunities ranging from modelling human development in vitro to personalised …

With the development of sequencing technology and the dramatic drop in sequencing cost,
the functions of noncoding genes are being characterized in a wide variety of fields (eg …

The cancer genome is characterized by extensive variability, in the form of Single Nucleotide
Polymorphisms (SNPs) or structural variations such as Copy Number Alterations (CNAs) …

Early developmental environment can influence long-term health through reprogramming of
the epigenome. Human environmental epigenetics studies rely on surrogate tissues, such …

Metazoa gene expression is controlled by modular DNA segments called cis-regulatory
modules (CRMs). CRMs can convey promoter/enhancer/insulator roles, generating …

Transcription regulation in metazoa is controlled by the binding events of transcription
factors (TFs) or regulatory proteins on specific modular DNA regulatory sequences called cis …

Estrogen receptor-positive (ER+) breast cancer accounts for the majority of breast cancers
diagnosed, and nearly 20% of patients do not respond to endocrine therapy. The …

The 20 short tandem repeat (STR) loci of the combined DNA index system (CODIS) are the
basis of the vast majority of forensic genetics in the United States. One argument for …

Dynamic regulation of chromatin accessibility is a key feature of cellular differentiation
during embryogenesis, but the precise factors that control access to chromatin remain …