Recent years have seen significant advances in our understanding of the development and
function of the adrenal gland together with further insights into the physiologic and …

Adverse effects of glucocorticoids have been abundantly reported. Published reports on low
dose glucocorticoid treatment show that few of the commonly held beliefs about their …

An important requirement for physiologic homeostasis is the detoxification and removal of
endogenous hormones and xenobiotic compounds with biological activity. Much of the …

Nuclear hormone receptors comprise a large superfamily of ligand-modulated transcription
factors that, in part, mediate response to steroids, retinoids and thyroid hormones and play …

I. Introduction M ANY alterations in endocrine function have been reported in association
with human immunodeficiency virus (HTV) infection and the acquired immune deficiency …

Adrenocortical insufficiency causes difficulty in diagnosis and morbidity out of proportion to
its rarity, because of the non-specific, multi-system nature of the clinical features. Most of …

This clinical practice guideline of the diagnosis and treatment of adrenal insufficiency (AI)
including adrenal crisis was produced on behalf of the Japan Endocrine Society. This …

Normal reproductive development depends on the interplay of steroid hormones with their
receptors at specific tissue sites. The concentrations of hormone ligands in the circulation …

Abstract Context: The P450 enzyme CYP24A1 is the principal inactivator of vitamin D
metabolites. Biallelic loss-of-function mutations in CYP24A1 are associated with elevated …

All endocrinologists would like to make glucocorticoid replacement therapy for their
hypoadrenal patients as physiological as possible. Many would like the reassurance of a …