Addiction, the most severe form of substance use disorder, is a chronic brain disorder
molded by strong biosocial factors that has devastating consequences to individuals and to …

The past two decades have witnessed a dramatic accumulation of evidence indicating that
the excitatory amino acid glutamate plays an important role in drug addiction and …

Cocaine craving, seeking, and relapse are mediated, in part, by cocaine-induced adaptive
changes in the brain reward circuits. The nucleus accumbens (NAc) integrates and …

Methamphetamine (Meth) is a powerful illicit psychostimulant, widely used for recreational
purposes. Besides disrupting the monoaminergic system and promoting oxidative brain …

All addictive drugs facilitate dopamine transmission, and determining the role of dopamine
has been the predominant focus of biomedical research in addiction for 20 years. Newer …

To identify the molecular mechanisms underlying psychostimulant-elicited plasticity in the
brain reward system, we undertook a phenotype-driven approach using genome-wide …

Substance abuse and addiction are the most costly of all the neuropsychiatric disorders. In
the last decades, much progress has been achieved in understanding the effects of the …

The inbred mouse C57BL/6J is the reference strain for genome sequence and for most
behavioral and physiological phenotypes. However, the International Knockout Mouse …

Modulation of N-acetyl-l-aspartyl-l-glutamate peptidase activity with small-molecule
inhibitors holds promise for a wide variety of diseases that involve glutamatergic …

MeCP2 is a methyl DNA–binding transcriptional regulator that contributes to the
development and function of CNS synapses; however, the requirement for MeCP2 in …