Photoredox catalysis (PRC) is a cutting-edge frontier for single electron-transfer (SET)
reactions, enabling the generation of reactive intermediates for both oxidative and reductive …

Serotonin (5-HT) receptors are part of the G protein-coupled and ligand-gated ion channel
families. 5-HT exerts its diverse actions by binding to cell surface receptors which can be …

An electrophotochemical ring-opening bromination of unstrained tert-cycloalkanols has
been developed. This electrophotochemical method enables the oxidative transformation of …

Rationale Major depressive disorder is a psychiatric disorder that requires considerable
attention, since it dramatically impairs the quality of life of the sufferers. The available …

Enterochromaffin (EC) cells of the epithelial cells release 5-HT into the lumen, as well as
basolateral border. However, the physiological role of released 5-HT into the lumen is poorly …

Crystallization outcomes, polymorph stability rankings, and phase transformation pathways
can be significantly altered when crystallization is restricted to dimensions below 1 μm. In …

Serotonin [5-hydroxytryptamine (5-HT)] acts as a modulator of colonic motility and secretion.
We characterized the action of the 5-HT precursor 5-hydroxytryptophan (5-HTP) on colonic …

Sphingolipid biosynthesis pathways have recently emerged as a promising target for
therapeutic intervention against pathogens, including parasites. A key step in the synthesis …

Diastereoisomeric compounds [18F] cis-and [18F] trans-4-methylbenzyl 4-[(pyrimidin-2-
ylamino) methyl]-3-fluoro-piperidine-1-carboxylates were successfully synthesized as new …

Abstract The serotonin type 4 receptor (5-HT 4 R) shows promise as a target for treating
major depressive disorder (MDD). Studies have demonstrated that 5-HT 4 R agonists have a …