Type 2 diabetes is a serious and common chronic disease resulting from a complex
inheritance-environment interaction along with other risk factors such as obesity and …

Type 2 diabetes mellitus (DM) is a chronic metabolic disorder in which prevalence has been
increasing steadily all over the world. As a result of this trend, it is fast becoming an epidemic …

Type 2 diabetes mellitus is the most prevalent metabolic disorder characterized by
hyperglycemia, hyperlipidemia as well as insulin resistance and is affecting the lives of a …

The broad expression of the insulin receptor suggests that the spectrum of insulin function
has not been fully described. A cell type expressing this receptor is the osteoblast, a bone …

Patients with diabetes type 2 have an increased risk for cardiovascular disease and
commonly use combination therapy consisting of the anti-diabetic drug metformin and a …

Increasing evidence supports an association between the skeleton and energy metabolism.
These interactions are mediated by a variety of hormones, cytokines and nutrients. Here, the …

CYP2C9 is a phase I drug-metabolizing cytochrome P450 (CYP450) enzyme isoform that
plays a major role in the oxidation of both xenobiotic and endogenous compounds. Gray et …

Type 2 diabetes (T2DM) is a complex disease combining defects in insulin secretion and
insulin action. New compounds have been developed for improving glucose‐induced …

Osteocalcin originates from osteoblastic synthesis and is deposited into bone or released
into circulation, where it correlates with histological measures of bone formation. The …

OBJECTIVE To assess the interplay between metformin treatment and thyroid function in
type 2 diabetic patients. RESEARCH DESIGN AND METHODS The acute and long-term …