Analysis of tissue specimens by matrix-assisted laser desorption/ionization imaging mass spectrometry in biological and clinical research

JL Norris, RM Caprioli - Chemical reviews, 2013 - ACS Publications
Human beings are adept at discerning relevant information from complex systems by
processing visual information. Similarly, as scientists labor to understand the fundamental …

Mass spectrometric imaging for biomedical tissue analysis

K Chughtai, RMA Heeren - Chemical reviews, 2010 - ACS Publications
A mass spectrometer is described as the smallest weighing scale ever used in the world. 1
Mass spectrometry (MS) is a unique technique that has an interdisciplinary nature, which …

Mass spectrometry imaging with high resolution in mass and space

A Römpp, B Spengler - Histochemistry and cell biology, 2013 - Springer
Mass spectrometry (MS) imaging links molecular information and the spatial distribution of
analytes within a sample. In contrast to most histochemical techniques, mass spectrometry …

MALDI imaging mass spectrometry: molecular snapshots of biochemical systems

DS Cornett, ML Reyzer, P Chaurand, RM Caprioli - Nature methods, 2007 - nature.com
Matrix-assisted laser desorption/ionization (MALDI) imaging mass spectrometry (IMS) is
emerging as a powerful tool for investigating the distribution of molecules within biological …

Sample preparation for mass spectrometry imaging: small mistakes can lead to big consequences

RJA Goodwin - Journal of proteomics, 2012 - Elsevier
Mass spectrometry imaging (MSI) enables the direct analysis of molecules from the surface
of a wide variety of samples, allowing the multiplex measurement of both abundance and …

The extracellular matrix in pancreatic cancer: description of a complex network and promising therapeutic options

B Ferrara, C Pignatelli, M Cossutta, A Citro, J Courty… - Cancers, 2021 - mdpi.com
Simple Summary This review depicts the principal mechanisms involved in the process of
stromal desmoplasia characterizing pancreatic ductal adenocarcinoma (PDAC). The aim of …

MALDI imaging mass spectrometry for direct tissue analysis: a new frontier for molecular histology

A Walch, S Rauser, SO Deininger, H Höfler - Histochemistry and cell …, 2008 - Springer
Matrix-assisted laser desorption/ionization (MALDI) imaging mass spectrometry (IMS) is a
powerful tool for investigating the distribution of proteins and small molecules within …

MALDI-FTICR imaging mass spectrometry of drugs and metabolites in tissue

DS Cornett, SL Frappier, RM Caprioli - Analytical chemistry, 2008 - ACS Publications
A new approach is described for imaging mass spectrometry analysis of drugs and
metabolites in tissue using matrix-assisted laser desorption ionization-Fourier transform ion …

Enhancement of protein sensitivity for MALDI imaging mass spectrometry after chemical treatment of tissue sections

EH Seeley, SR Oppenheimer, D Mi… - Journal of the American …, 2008 - Springer
MALDI imaging mass spectrometry (IMS) has become a valuable tool for the investigation of
the content and distribution of molecular species in tissue specimens. Numerous …

Optimization and comparison of multiple MALDI matrix application methods for small molecule mass spectrometric imaging

E Gemperline, S Rawson, L Li - Analytical chemistry, 2014 - ACS Publications
The matrix application technique is critical to the success of a matrix-assisted laser
desorption/ionization (MALDI) experiment. This work presents a systematic study aiming to …