Among the various types of cell-to-cell signaling, paracrine signaling comprises those
signals that are transmitted over short distances between different cell types. In the human …

Observations made in the last few years support the existence of pathways, in adult humans
and rodents, that allow adult stem cells to be surprisingly flexible in their differentiation …

Embryonic stem cells are immortal, can self renew, and differentiate into all cells of the body.
The adult organism maintains adult stem cells in regenerative organs that can differentiate …

Sickle cell disease (SCD) is characterized by a point mutation that replaces adenine with
thymidine in the sixth codon of the β-globin gene, a unique morphological abnormality of red …

The nature and exact function of selectin ligands involved in hematopoietic progenitor cell
(HPC) homing to the bone marrow (BM) are unclear. Using murine progenitor homing …

Adult stem cells are essential to maintain regenerative tissues such as skin epidermis,
gastrointestinal mucosa or the hematopoietic system. Recent studies in mice suggest that …

Neutrophils play a critical role in the acute inflammatory response and host-defenses
against bacterial infections. Neutropenia, a deficiency of these cells, predisposes to …

Biochemical and molecular genetic studies have revealed that blood group antigens are
present on cell surface molecules of wide structural diversity, including carbohydrate …

ICAM-4 (LW blood group glycoprotein) is an erythroid-specific membrane component that
belongs to the family of intercellular adhesion molecules and interacts in vitrowith different …

Physiological interactions between the nervous and immune systems with components of
the local microenvironment are needed to maintain homeostasis throughout the body …