Platelet endothelial cell adhesion molecule-1 (PECAM-1)(CD31) is an adhesion molecule
expressed on endothelial cells and subsets of leukocytes. Analysis of phenotypically defined …

There has recently been a significant change in the way we think about organ regeneration.
In the adult, organ formation and regeneration was thought to occur through the action of …

Background: The severity of sickle cell disease (SCD) increases with leukocyte count. The
biological basis could be that leukocyte adherence to vascular endothelium mediated by …

Mouse embryonic stem (ES) cells can proliferate indefinitely in an undifferentiated state in
the presence of leukemia inhibitory factor (LIF), or differentiate into all three germ layers …

The ultimate aim of stem cell research is to improve patient outcomes and quality of life,
and/or to effect a cure for a variety of inherited or acquired diseases. Improved treatments …

Ecotropic viral integration site-1 (EVI1) is one of the candidate oncogenes for human acute
myeloid leukemia (AML) with chromosomal alterations at 3q26. High EVI1 expression …

Acute promyelocytic leukaemia (APL) with M3 (or M3v) morphology is the only AML subtype
to date for which morphology and immunophenotype agree. In other words, FAB M3 is …

Background Hematopoietic stem and progenitor cells can interact with their
microenvironment via integrins which are adhesion receptors consisting of α and β subunits …

Previous studies have shown that α4β1 (very late activation antigen-4 [VLA-4]) and vascular
cell adhesion molecule-1 (VCAM-1) play a major role in hematopoietic progenitor cell (HPC) …

Background The availability of genotype‐specific therapy for PML/RARαpos acute
promyelocytic leukemia (APL) requires that this disease be precisely diagnosed …