Metabolism pathways of arachidonic acids: mechanisms and potential therapeutic targets

B Wang, L Wu, J Chen, L Dong, C Chen… - Signal transduction and …, 2021 - nature.com
The arachidonic acid (AA) pathway plays a key role in cardiovascular biology,
carcinogenesis, and many inflammatory diseases, such as asthma, arthritis, etc. Esterified …

Macrophages: the good, the bad, and the gluttony

EA Ross, A Devitt, JR Johnson - Frontiers in immunology, 2021 - frontiersin.org
Macrophages are dynamic cells that play critical roles in the induction and resolution of
sterile inflammation. In this review, we will compile and interpret recent findings on the …

NF‐κB signaling in inflammation and cancer

T Zhang, C Ma, Z Zhang, H Zhang, H Hu - MedComm, 2021 - Wiley Online Library
Since nuclear factor of κ‐light chain of enhancer‐activated B cells (NF‐κB) was discovered
in 1986, extraordinary efforts have been made to understand the function and regulating …

Update on the pathomechanism, diagnosis, and treatment options for rheumatoid arthritis

YJ Lin, M Anzaghe, S Schülke - Cells, 2020 - mdpi.com
Rheumatoid arthritis (RA) is an autoimmune disease that involves multiple joints bilaterally.
It is characterized by an inflammation of the tendon (tenosynovitis) resulting in both cartilage …

[HTML][HTML] Epstein-Barr virus and systemic autoimmune diseases

G Houen, NH Trier - Frontiers in immunology, 2021 - frontiersin.org
Epstein-Barr Virus (EBV) is an extremely successful human herpes virus, which infects
essentially all human beings at some time during their life span. EBV infection and the …

Recent advances in understanding the pathogenesis of rheumatoid arthritis: new treatment strategies

AL Mueller, Z Payandeh, N Mohammadkhani… - Cells, 2021 - mdpi.com
Rheumatoid arthritis (RA) is considered a chronic systemic, multi-factorial, inflammatory, and
progressive autoimmune disease affecting many people worldwide. While patients show …

[HTML][HTML] Nanoenzyme engineered neutrophil-derived exosomes attenuate joint injury in advanced rheumatoid arthritis via regulating inflammatory environment

L Zhang, Z Qin, H Sun, X Chen, J Dong, S Shen… - Bioactive materials, 2022 - Elsevier
Rheumatoid arthritis (RA) is a chronic inflammatory disease characterized by synovitis and
destruction of cartilage, promoted by sustained inflammation. However, current treatments …

Toll-like receptors as a therapeutic target in the era of immunotherapies

M Farooq, M Batool, MS Kim, S Choi - Frontiers in Cell and …, 2021 - frontiersin.org
Toll-like receptors (TLRs) are the pattern recognition receptors, which are activated by
foreign and host molecules in order to initiate the immune response. They play a crucial role …

[HTML][HTML] Disease modifying anti-rheumatic drugs (DMARD)

O Benjamin, A Goyal, SL Lappin - 2018 - europepmc.org
Objectives: Explain the difference between traditional and biological DMARDs. Identify the
indications for various DMARD agents. Outline the adverse effects and contraindications to …

Associations of blood and urinary heavy metals with rheumatoid arthritis risk among adults in NHANES, 1999–2018

L Chen, Q Sun, S Peng, T Tan, G Mei, H Chen, Y Zhao… - Chemosphere, 2022 - Elsevier
Heavy metals exposure has been widely recognized as a risk factor for human health.
However, limited information is available about the impacts of heavy metals on rheumatoid …