Imidazopyridine hydrazone derivatives exert antiproliferative effect on lung and pancreatic cancer cells and potentially inhibit receptor tyrosine kinases including c-Met
Aberrant activation of c-Met signalling plays a prominent role in cancer development and
progression. A series of 12 imidazo [1, 2-α] pyridine derivatives bearing 1, 2, 3-triazole …
progression. A series of 12 imidazo [1, 2-α] pyridine derivatives bearing 1, 2, 3-triazole …
Molecular insights of metastasis and cancer progression derived using 3D cancer spheroid co-culture in vitro platform
The multistep metastasis process is carried out by the combinatorial effect of the stromal
cells and the cancerous cells and plays vital role in the cancer progression. The …
cells and the cancerous cells and plays vital role in the cancer progression. The …
Biodegradable ultrasmall-in-nano architectures loaded with cisplatin prodrug in combination with ionizing radiation induces DNA damage and apoptosis in pancreatic …
PP Che, AK Mapanao, A Gregori, ML Ermini… - Cancers, 2022 - mdpi.com
Simple Summary The occurrence of severe normal tissue side effects and acquired drug
resistance of the malignancy are the most important limitations that are associated with …
resistance of the malignancy are the most important limitations that are associated with …
Impact of hypoxia on chemoresistance of mesothelioma mediated by the proton-coupled folate transporter, and preclinical activity of new anti-LDH-A compounds
G Li Petri, B El Hassouni, R Sciarrillo, N Funel… - British journal of …, 2020 - nature.com
Background Expression of proton-coupled folate transporter (PCFT) is associated with
survival of mesothelioma patients treated with pemetrexed, and is reduced by hypoxia …
survival of mesothelioma patients treated with pemetrexed, and is reduced by hypoxia …
Integrated single-cell and bulk RNA sequencing in pancreatic cancer identifies disulfidptosis-associated molecular subtypes and prognostic signature
Y Wu, J Shang, Q Ruan, X Tan - Scientific Reports, 2023 - nature.com
Pancreatic cancer (PC) is known for its high degree of heterogeneity and exceptionally
adverse outcome. While disulfidptosis is the most recently identified form of cell death, the …
adverse outcome. While disulfidptosis is the most recently identified form of cell death, the …
Co-expression analysis of pancreatic cancer proteome reveals biology and prognostic biomarkers
G Mantini, AM Vallés, TYS Le Large, M Capula… - Cellular oncology, 2020 - Springer
Purpose Despite extensive biological and clinical studies, including comprehensive
genomic and transcriptomic profiling efforts, pancreatic ductal adenocarcinoma (PDAC) …
genomic and transcriptomic profiling efforts, pancreatic ductal adenocarcinoma (PDAC) …
Epithelial and mesenchymal features of pancreatic ductal adenocarcinoma cell lines in two-and three-dimensional cultures
Y Shichi, F Gomi, N Sasaki, K Nonaka, T Arai… - Journal of Personalized …, 2022 - mdpi.com
Pancreatic ductal adenocarcinoma (PDAC) is an intractable cancer that is difficult to
diagnose early, and there is no cure other than surgery. PDAC is classified as an …
diagnose early, and there is no cure other than surgery. PDAC is classified as an …
Novel quinazoline-1, 2, 3-triazole hybrids with anticancer and MET kinase targeting properties
M Mortazavi, M Eskandari, F Moosavi, T Damghani… - Scientific Reports, 2023 - nature.com
Oncogenic activation of receptor tyrosine kinases (RTKs) such as MET is associated with
cancer initiation and progression. We designed and synthesized a new series of quinazoline …
cancer initiation and progression. We designed and synthesized a new series of quinazoline …
Synergistic eradicating impact of 5-fluouracil with FeO nanoparticles-diethyldithiocarbamate in colon cancer spheroids
MM Abu-Serie - Nanomedicine, 2024 - Taylor & Francis
Background: Cancer stem cells'(CSCs) resistance to 5-fluorouracil (Fu), which is the main
obstacle in treating colon cancer (CC), can be overcome by ferroptosis. The latter, herein …
obstacle in treating colon cancer (CC), can be overcome by ferroptosis. The latter, herein …
Chemotherapy assessment in advanced multicellular 3D models of pancreatic cancer: Unravelling the importance of spatiotemporal mimicry of the tumor …
Pancreatic ductal adenocarcinoma (PDAC) is a challenge for global health with very low
survival rate and high therapeutic resistance. Hence, advanced preclinical models for …
survival rate and high therapeutic resistance. Hence, advanced preclinical models for …