Genetic-guided risk assessment and management of thyroid cancer

M Xing - Endocrinology and Metabolism Clinics, 2019 - endo.theclinics.com
Thyroid cancer is a common endocrine malignancy, which histologically includes follicular
epithelial cell–derived thyroid cancer and parafollicular C-cell–derived medullary thyroid …

TERT promoter mutations in thyroid cancer

M Matsuse, N Mitsutake - Endocrine journal, 2023 - jstage.jst.go.jp
TERT promoter mutations (TERT-p mutations) have been found in many types of cancer and
have emerged to play critical roles in tumor progression. The mutations upregulate TERT …

TERT mRNA Expression as a Novel Prognostic Marker in Papillary Thyroid Carcinomas

A Tanaka, M Matsuse, V Saenko, T Nakao… - Thyroid, 2019 - liebertpub.com
Background: Telomerase reverse transcriptase (TERT) promoter mutations have been found
in a subset of papillary thyroid carcinomas (PTCs) and are associated with tumor …

A six-genotype genetic prognostic model for papillary thyroid cancer

X Shen, R Liu, M Xing - Endocrine-related cancer, 2017 - erc.bioscientifica.com
A unique prognostic role of the genetic duet of BRAF V600E and TERT promoter mutations
in papillary thyroid cancer (PTC) has been recently established, but the role of RAS mutation …

Single point mutations in pediatric differentiated thyroid cancer

AS Alzahrani, AK Murugan, E Qasem, M Alswailem… - Thyroid, 2017 - liebertpub.com
Purpose: Differentiated thyroid cancer (DTC) is rare in children. Previous studies have
suggested that it has different clinicopathologic features and mutation profiles compared …

BRAF and TERT promoter mutations: clinical application in thyroid cancer

JH Chung - Endocrine Journal, 2020 - jstage.jst.go.jp
Given the long-term survival of most patients with thyroid cancer, it is very important to
distinguish patients who need aggressive treatment from those who do not. Conventional …

TERT promoter mutations and Ki-67 labeling index as a prognostic marker of papillary thyroid carcinomas: combination of two independent factors

M Matsuse, T Yabuta, V Saenko, M Hirokawa… - Scientific reports, 2017 - nature.com
Although most papillary thyroid carcinomas (PTCs) have a good prognosis, a small but
certain fraction shows aggressive behavior. Therefore, a novel and well-performing …

[HTML][HTML] Overwhelming rapid metabolic and structural response to apatinib in radioiodine refractory differentiated thyroid cancer

Y Lin, C Wang, W Gao, R Cui, J Liang - Oncotarget, 2017 - ncbi.nlm.nih.gov
Currently, patients with radioiodine refractory differentiated thyroid cancer (RAIR-DTC) have
limited treatment options. In this study, we aimed to assess the short-term efficacy and safety …

TERT promoter and BRAF V600E mutations in papillary thyroid cancer: a single-institution experience in Korea

MJ Kim, JK Kim, GJ Kim, SW Kang, J Lee, JJ Jeong… - Cancers, 2022 - mdpi.com
Simple Summary TERT promoter mutation has recently emerged as a promising prognostic
biomarker for aggressive papillary thyroid cancer (PTC), along with BRAF B600E mutation …

Clinical significance and diagnostic value of QPCT, SCEL and TNFRSF12A in papillary thyroid cancer

T Liang, X Wu, L Wang, Z Ni, Y Fan, P Wu… - … -Research and Practice, 2023 - Elsevier
Purpose To identify specific novel genes that could be used as diagnostic and prognostic
factors in papillary thyroid carcinoma (PTC). Methods Screening of differential genes by …