Applications of long-read sequencing to Mendelian genetics
Advances in clinical genetic testing, including the introduction of exome sequencing, have
uncovered the molecular etiology for many rare and previously unsolved genetic disorders …
uncovered the molecular etiology for many rare and previously unsolved genetic disorders …
Human papillomavirus genomics: Understanding carcinogenicity
CW Nelson, L Mirabello - Tumour Virus Research, 2023 - Elsevier
Human papillomavirus (HPV) causes virtually all cervical cancers and many cancers at other
anatomical sites in both men and women. However, only 12 of 448 known HPV types are …
anatomical sites in both men and women. However, only 12 of 448 known HPV types are …
Intratumoral heterogeneity and clonal evolution induced by HPV integration
The human papillomavirus (HPV) genome is integrated into host DNA in most HPV-positive
cancers, but the consequences for chromosomal integrity are unknown. Continuous long …
cancers, but the consequences for chromosomal integrity are unknown. Continuous long …
Human papillomavirus 42 drives digital papillary adenocarcinoma and elicits a germ cell–like program conserved in HPV-positive cancers
The skin is exposed to viral pathogens, but whether they contribute to the oncogenesis of
skin cancers has not been systematically explored. Here we investigated 19 skin tumor …
skin cancers has not been systematically explored. Here we investigated 19 skin tumor …
CRISPR-Cas-Driven Single Micromotor (Cas-DSM) Enables Direct Detection of Nucleic Acid Biomarkers at the Single-Molecule Level
D Chen, Y Liang, H Wang, H Wang, F Su… - Analytical …, 2023 - ACS Publications
The target-dependent endonuclease activity (also known as the trans-cleavage activity) of
CRISPR-Cas systems has stimulated great interest in the development of nascent sensing …
CRISPR-Cas systems has stimulated great interest in the development of nascent sensing …
Rational design of genotyping nanodevice for HPV subtype distinction
YJ Jiang, KH Nie, J Li, YF Li, CZ Huang, CM Li - Analytica Chimica Acta, 2023 - Elsevier
There are more than 200 subtypes of human papillomavirus (HPV), and high-risk HPVs are
a leading cause of cervical cancer. Identifying the genotypes of HPV is significant for clinical …
a leading cause of cervical cancer. Identifying the genotypes of HPV is significant for clinical …
HPV oncogenes expressed from only one of multiple integrated HPV DNA copies drive clonal cell expansion in cervical cancer
L Yu, V Majerciak, A Lobanov, S Mirza, V Band, H Liu… - Mbio, 2024 - Am Soc Microbiol
The integration of HPV DNA into human chromosomes plays a pivotal role in the onset of
papillomavirus-related cancers. HPV DNA integration often occurs by linearizing the viral …
papillomavirus-related cancers. HPV DNA integration often occurs by linearizing the viral …
The analysis of HPV integration sites based on nanopore sequencing and the profiling changes along the course of photodynamic therapy
X Li, X Wei, X Liu, N Wang, F Xu, X Liu, Y Li, Y Zhou… - BMC cancer, 2023 - Springer
Objective To detect the HPV genotype and integration sites in patients with high-risk HPV
infection at different stages of photodynamic therapy using nanopore technology and to …
infection at different stages of photodynamic therapy using nanopore technology and to …
Molecular aspects of cervical cancer: a pathogenesis update
V Vallejo-Ruiz, L Gutierrez-Xicotencatl… - Frontiers in …, 2024 - frontiersin.org
Cervical cancer (CC) is a significant health problem, especially in low-income countries.
Functional studies on the human papillomavirus have generated essential advances in the …
Functional studies on the human papillomavirus have generated essential advances in the …
Protein–DNA interactions regulate human papillomavirus DNA replication, transcription, and oncogenesis
R Evande, A Rana, EE Biswas-Fiss… - International Journal of …, 2023 - mdpi.com
Human papillomavirus (HPV) is a group of alpha papillomaviruses that cause various
illnesses, including cancer. There are more than 160 types of HPV, with many being “high …
illnesses, including cancer. There are more than 160 types of HPV, with many being “high …