Mechanisms and regulation of endothelial VEGF receptor signalling
M Simons, E Gordon, L Claesson-Welsh - Nature reviews Molecular …, 2016 - nature.com
Vascular endothelial growth factors (VEGFs) and their receptors (VEGFRs) are uniquely
required to balance the formation of new blood vessels with the maintenance and …
required to balance the formation of new blood vessels with the maintenance and …
[HTML][HTML] Molecular pharmacology of VEGF-A isoforms: binding and signalling at VEGFR2
Vascular endothelial growth factor-A (VEGF-A) is a key mediator of angiogenesis, signalling
via the class IV tyrosine kinase receptor family of VEGF Receptors (VEGFRs). Although …
via the class IV tyrosine kinase receptor family of VEGF Receptors (VEGFRs). Although …
Inhibition of FGF‐FGFR and VEGF‐VEGFR signalling in cancer treatment
G Liu, T Chen, Z Ding, Y Wang, Y Wei, X Wei - Cell proliferation, 2021 - Wiley Online Library
The sites of targeted therapy are limited and need to be expanded. The FGF‐FGFR
signalling plays pivotal roles in the oncogenic process, and FGF/FGFR inhibitors are a …
signalling plays pivotal roles in the oncogenic process, and FGF/FGFR inhibitors are a …
Signal transduction by vascular endothelial growth factor receptors
S Koch, L Claesson-Welsh - Cold Spring …, 2012 - perspectivesinmedicine.cshlp.org
Vascular endothelial growth factors (VEGFs) are master regulators of vascular development
and of blood and lymphatic vessel function during health and disease in the adult. It is …
and of blood and lymphatic vessel function during health and disease in the adult. It is …
Signal transduction by vascular endothelial growth factor receptors
S Koch, S Tugues, X Li, L Gualandi… - Biochemical …, 2011 - portlandpress.com
VEGFs (vascular endothelial growth factors) control vascular development during
embryogenesis and the function of blood vessels and lymphatic vessels in the adult. There …
embryogenesis and the function of blood vessels and lymphatic vessels in the adult. There …
[HTML][HTML] VEGFR1 signaling in retinal angiogenesis and microinflammation
Five vascular endothelial growth factor receptor (VEGFR) ligands (VEGF-A,-B,–C,-D, and
placental growth factor [PlGF]) constitute the VEGF family. VEGF-A binds VEGF receptors 1 …
placental growth factor [PlGF]) constitute the VEGF family. VEGF-A binds VEGF receptors 1 …
Positive and negative modulation of angiogenesis by VEGFR1 ligands
Y Cao - Science signaling, 2009 - science.org
Vascular endothelial growth factor–A (VEGF-A) is a key target for new antiangiogenic drugs
for the treatment of both malignant and nonmalignant human diseases. Vascular effects of …
for the treatment of both malignant and nonmalignant human diseases. Vascular effects of …
Vascular endothelial growth factor receptor-2 in breast cancer
S Guo, LS Colbert, M Fuller, Y Zhang… - … et Biophysica Acta (BBA …, 2010 - Elsevier
Investigations over the last decade have established the essential role of growth factors and
their receptors during angiogenesis and carcinogenesis. The vascular endothelial growth …
their receptors during angiogenesis and carcinogenesis. The vascular endothelial growth …
[HTML][HTML] Structural basis for vascular endothelial growth factor receptor activation and implications for disease therapy
F Shaik, GA Cuthbert, S Homer-Vanniasinkam… - Biomolecules, 2020 - mdpi.com
Vascular endothelial growth factors (VEGFs) bind to membrane receptors on a wide variety
of cells to regulate diverse biological responses. The VEGF-A family member promotes …
of cells to regulate diverse biological responses. The VEGF-A family member promotes …
A systems biology perspective on sVEGFR1: its biological function, pathogenic role and therapeutic use
FTH Wu, MO Stefanini, FM Gabhann… - Journal of cellular …, 2010 - Wiley Online Library
Introduction‐Angiogenesis in physiology and pathology‐Angiogenesis in current medicine‐
VEGF ligand and receptor system: where does sVEGFR1 fit?‐Ligands: the human VEGF …
VEGF ligand and receptor system: where does sVEGFR1 fit?‐Ligands: the human VEGF …